High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia

<h4>Background</h4> Because of limited infrastructure and skilled human capital, the etiology of meningitis is rarely identified in developing countries like Ethiopia. This results in unnecessary antibiotics use, economic crisis, hospitalization, and related nosocomial infections. Thus,...

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Autores principales:	Ashenafi Alemu Wami, Gadissa Bedada Hundie, Rozina Ambachew, Zenebe Gebreyohannes Berhe, Alem Abrha, Workeabeba Abebe, Dessalegen Abeje, Alene Geteneh, Adane Mihret, Andargachew Mulu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6ceb1aa38254feebf67d1c269b66d95
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spelling	oai:doaj.org-article:b6ceb1aa38254feebf67d1c269b66d952021-11-18T08:14:35ZHigh rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia1932-6203https://doaj.org/article/b6ceb1aa38254feebf67d1c269b66d952021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584720/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Because of limited infrastructure and skilled human capital, the etiology of meningitis is rarely identified in developing countries like Ethiopia. This results in unnecessary antibiotics use, economic crisis, hospitalization, and related nosocomial infections. Thus, we aimed to assess the epidemiology of human enteroviruses (HEVs) among clinically suspected meningitis cases in Addis Ababa, Ethiopia. <h4>Method</h4> A cross-sectional study was conducted from January to August 2020 at selected Hospitals in Addis Ababa, Ethiopia. Reverse transcriptase-polymerase chain reaction (RT-PCR) was conducted on cerebrospinal fluid (CSF) collected from 146 clinically suspected meningitis and bacterial culture-negative patients. SPSS v 21.0 was used for data analysis and bivariate correlation was done for the association between variables of interest. <h4>Results</h4> HEVs were detected in 39 (26.7%) of the 146 clinically suspected meningitis cases. Most of the HEVs cases 28 (71.9%) were detected in younger-aged infants less than 1 year. The most commonly observed clinical manifestations were vomiting (75.5%) followed by fever (56.8%) and impaired consciousness or irritability (50.7%). The mean length of hospital stay for patients with enteroviral meningitis was 9 days. Many patients with HEVs were recovered with sequelae (46.2%), and HEVs has contributed for one out of the nine meningeal deaths (11.1%). <h4>Conclusions</h4> HEVs were found to be the commonest cause of morbidity and mortality in all age groups. Many of the patients were mistreated with antibiotics and hospitalized. The detection of HEVs in 26.7% of clinically suspected meningitis cases indicated the need for molecular tests in investigating the etiology of meningitis. Therefore, we suggest the introduction of molecular tests as a routine practice in referral hospitals and the need to further characterize circulating HEVs strains.Ashenafi Alemu WamiGadissa Bedada HundieRozina AmbachewZenebe Gebreyohannes BerheAlem AbrhaWorkeabeba AbebeDessalegen AbejeAlene GetenehAdane MihretAndargachew MuluPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashenafi Alemu Wami Gadissa Bedada Hundie Rozina Ambachew Zenebe Gebreyohannes Berhe Alem Abrha Workeabeba Abebe Dessalegen Abeje Alene Geteneh Adane Mihret Andargachew Mulu High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia
description	<h4>Background</h4> Because of limited infrastructure and skilled human capital, the etiology of meningitis is rarely identified in developing countries like Ethiopia. This results in unnecessary antibiotics use, economic crisis, hospitalization, and related nosocomial infections. Thus, we aimed to assess the epidemiology of human enteroviruses (HEVs) among clinically suspected meningitis cases in Addis Ababa, Ethiopia. <h4>Method</h4> A cross-sectional study was conducted from January to August 2020 at selected Hospitals in Addis Ababa, Ethiopia. Reverse transcriptase-polymerase chain reaction (RT-PCR) was conducted on cerebrospinal fluid (CSF) collected from 146 clinically suspected meningitis and bacterial culture-negative patients. SPSS v 21.0 was used for data analysis and bivariate correlation was done for the association between variables of interest. <h4>Results</h4> HEVs were detected in 39 (26.7%) of the 146 clinically suspected meningitis cases. Most of the HEVs cases 28 (71.9%) were detected in younger-aged infants less than 1 year. The most commonly observed clinical manifestations were vomiting (75.5%) followed by fever (56.8%) and impaired consciousness or irritability (50.7%). The mean length of hospital stay for patients with enteroviral meningitis was 9 days. Many patients with HEVs were recovered with sequelae (46.2%), and HEVs has contributed for one out of the nine meningeal deaths (11.1%). <h4>Conclusions</h4> HEVs were found to be the commonest cause of morbidity and mortality in all age groups. Many of the patients were mistreated with antibiotics and hospitalized. The detection of HEVs in 26.7% of clinically suspected meningitis cases indicated the need for molecular tests in investigating the etiology of meningitis. Therefore, we suggest the introduction of molecular tests as a routine practice in referral hospitals and the need to further characterize circulating HEVs strains.
format	article
author	Ashenafi Alemu Wami Gadissa Bedada Hundie Rozina Ambachew Zenebe Gebreyohannes Berhe Alem Abrha Workeabeba Abebe Dessalegen Abeje Alene Geteneh Adane Mihret Andargachew Mulu
author_facet	Ashenafi Alemu Wami Gadissa Bedada Hundie Rozina Ambachew Zenebe Gebreyohannes Berhe Alem Abrha Workeabeba Abebe Dessalegen Abeje Alene Geteneh Adane Mihret Andargachew Mulu
author_sort	Ashenafi Alemu Wami
title	High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia
title_short	High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia
title_full	High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia
title_fullStr	High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia
title_full_unstemmed	High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia
title_sort	high rate of human enteroviruses among clinically suspected meningitis cases at selected hospitals in addis ababa, ethiopia
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b6ceb1aa38254feebf67d1c269b66d95
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High rate of human enteroviruses among clinically suspected meningitis cases at selected Hospitals in Addis Ababa, Ethiopia

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