Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors

Zika virus (ZIKV) is an emerging global health issue, but currently no licensed vaccine achieves lasting protective immunity. Here the authors show that a ZIKV vaccine containing the envelop protein without the transmembrane domain and the precursor membrane protein can provide effective protection...

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Autores principales:	César López-Camacho, Peter Abbink, Rafael A. Larocca, Wanwisa Dejnirattisai, Michael Boyd, Alex Badamchi-Zadeh, Zoë R. Wallace, Jennifer Doig, Ricardo Sanchez Velazquez, Roberto Dias Lins Neto, Danilo F. Coelho, Young Chan Kim, Claire L. Donald, Ania Owsianka, Giuditta De Lorenzo, Alain Kohl, Sarah C. Gilbert, Lucy Dorrell, Juthathip Mongkolsapaya, Arvind H. Patel, Gavin R. Screaton, Dan H. Barouch, Adrian V. S. Hill, Arturo Reyes-Sandoval
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6cfc5f8887749b296b4b5719265b7c8
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spelling	oai:doaj.org-article:b6cfc5f8887749b296b4b5719265b7c82021-12-02T17:31:43ZRational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors10.1038/s41467-018-04859-52041-1723https://doaj.org/article/b6cfc5f8887749b296b4b5719265b7c82018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04859-5https://doaj.org/toc/2041-1723Zika virus (ZIKV) is an emerging global health issue, but currently no licensed vaccine achieves lasting protective immunity. Here the authors show that a ZIKV vaccine containing the envelop protein without the transmembrane domain and the precursor membrane protein can provide effective protection in mouse models.César López-CamachoPeter AbbinkRafael A. LaroccaWanwisa DejnirattisaiMichael BoydAlex Badamchi-ZadehZoë R. WallaceJennifer DoigRicardo Sanchez VelazquezRoberto Dias Lins NetoDanilo F. CoelhoYoung Chan KimClaire L. DonaldAnia OwsiankaGiuditta De LorenzoAlain KohlSarah C. GilbertLucy DorrellJuthathip MongkolsapayaArvind H. PatelGavin R. ScreatonDan H. BarouchAdrian V. S. HillArturo Reyes-SandovalNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q César López-Camacho Peter Abbink Rafael A. Larocca Wanwisa Dejnirattisai Michael Boyd Alex Badamchi-Zadeh Zoë R. Wallace Jennifer Doig Ricardo Sanchez Velazquez Roberto Dias Lins Neto Danilo F. Coelho Young Chan Kim Claire L. Donald Ania Owsianka Giuditta De Lorenzo Alain Kohl Sarah C. Gilbert Lucy Dorrell Juthathip Mongkolsapaya Arvind H. Patel Gavin R. Screaton Dan H. Barouch Adrian V. S. Hill Arturo Reyes-Sandoval Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
description	Zika virus (ZIKV) is an emerging global health issue, but currently no licensed vaccine achieves lasting protective immunity. Here the authors show that a ZIKV vaccine containing the envelop protein without the transmembrane domain and the precursor membrane protein can provide effective protection in mouse models.
format	article
author	César López-Camacho Peter Abbink Rafael A. Larocca Wanwisa Dejnirattisai Michael Boyd Alex Badamchi-Zadeh Zoë R. Wallace Jennifer Doig Ricardo Sanchez Velazquez Roberto Dias Lins Neto Danilo F. Coelho Young Chan Kim Claire L. Donald Ania Owsianka Giuditta De Lorenzo Alain Kohl Sarah C. Gilbert Lucy Dorrell Juthathip Mongkolsapaya Arvind H. Patel Gavin R. Screaton Dan H. Barouch Adrian V. S. Hill Arturo Reyes-Sandoval
author_facet	César López-Camacho Peter Abbink Rafael A. Larocca Wanwisa Dejnirattisai Michael Boyd Alex Badamchi-Zadeh Zoë R. Wallace Jennifer Doig Ricardo Sanchez Velazquez Roberto Dias Lins Neto Danilo F. Coelho Young Chan Kim Claire L. Donald Ania Owsianka Giuditta De Lorenzo Alain Kohl Sarah C. Gilbert Lucy Dorrell Juthathip Mongkolsapaya Arvind H. Patel Gavin R. Screaton Dan H. Barouch Adrian V. S. Hill Arturo Reyes-Sandoval
author_sort	César López-Camacho
title	Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_short	Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_full	Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_fullStr	Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_full_unstemmed	Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_sort	rational zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b6cfc5f8887749b296b4b5719265b7c8
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Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors

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