Clinical use of pregabalin in the management of central neuropathic pain

Nanna B Finnerup, Troels S JensenDanish Pain Research Center, Department of Neurology, Aarhus University Hospital, Aarhus, DenmarkAbstract: Central neuropathic pain (central pain) is treated with antidepressants, various anticonvulsants, opioids, and cannabinoids, but in many cases treatment is insu...

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Autores principales: Nanna B Finnerup, Troels S Jensen
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Lenguaje:EN
Publicado: Dove Medical Press 2007
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Acceso en línea:https://doaj.org/article/b6d57858933a4dbdb3d4f2a3dcca7e46
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spelling oai:doaj.org-article:b6d57858933a4dbdb3d4f2a3dcca7e462021-12-02T07:16:53ZClinical use of pregabalin in the management of central neuropathic pain1176-63281178-2021https://doaj.org/article/b6d57858933a4dbdb3d4f2a3dcca7e462007-01-01T00:00:00Zhttp://www.dovepress.com/clinical-use-of-pregabalin-in-the-management-of-central-neuropathic-pa-a966https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Nanna B Finnerup, Troels S JensenDanish Pain Research Center, Department of Neurology, Aarhus University Hospital, Aarhus, DenmarkAbstract: Central neuropathic pain (central pain) is treated with antidepressants, various anticonvulsants, opioids, and cannabinoids, but in many cases treatment is insufficient and associated with a range of side-effects. This review addresses a new treatment for neuropathic pain, the anticonvulsant pregabalin. We review the pharmacology, mode of action, pharmacokinetics, and safety of pregabalin as well as two randomized efficacy studies in central pain and a brief overview of efficacy in peripheral neuropathic pain. Pregabalin appears to have efficacy in treating central pain comparable to that in peripheral neuropathic pain as well as efficacy of other recommended drugs for central pain. Pregabalin also improves disturbed sleep and anxiety. Pregabalin is well tolerated; the most common side-effects are somnolence, dizziness, ataxia, and weight gain. Pregabalin is suitable for patients on multiple drugs although there may be additive CNS-related side-effects. Thus, pregabalin has a primary role in central pain patients.Keywords: central pain, neuropathic pain, pregabalin, pharmacology Nanna B FinnerupTroels S JensenDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2007, Iss Issue 6, Pp 885-891 (2007)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Nanna B Finnerup
Troels S Jensen
Clinical use of pregabalin in the management of central neuropathic pain
description Nanna B Finnerup, Troels S JensenDanish Pain Research Center, Department of Neurology, Aarhus University Hospital, Aarhus, DenmarkAbstract: Central neuropathic pain (central pain) is treated with antidepressants, various anticonvulsants, opioids, and cannabinoids, but in many cases treatment is insufficient and associated with a range of side-effects. This review addresses a new treatment for neuropathic pain, the anticonvulsant pregabalin. We review the pharmacology, mode of action, pharmacokinetics, and safety of pregabalin as well as two randomized efficacy studies in central pain and a brief overview of efficacy in peripheral neuropathic pain. Pregabalin appears to have efficacy in treating central pain comparable to that in peripheral neuropathic pain as well as efficacy of other recommended drugs for central pain. Pregabalin also improves disturbed sleep and anxiety. Pregabalin is well tolerated; the most common side-effects are somnolence, dizziness, ataxia, and weight gain. Pregabalin is suitable for patients on multiple drugs although there may be additive CNS-related side-effects. Thus, pregabalin has a primary role in central pain patients.Keywords: central pain, neuropathic pain, pregabalin, pharmacology
format article
author Nanna B Finnerup
Troels S Jensen
author_facet Nanna B Finnerup
Troels S Jensen
author_sort Nanna B Finnerup
title Clinical use of pregabalin in the management of central neuropathic pain
title_short Clinical use of pregabalin in the management of central neuropathic pain
title_full Clinical use of pregabalin in the management of central neuropathic pain
title_fullStr Clinical use of pregabalin in the management of central neuropathic pain
title_full_unstemmed Clinical use of pregabalin in the management of central neuropathic pain
title_sort clinical use of pregabalin in the management of central neuropathic pain
publisher Dove Medical Press
publishDate 2007
url https://doaj.org/article/b6d57858933a4dbdb3d4f2a3dcca7e46
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