Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

How cells migrate in fibrous tissues is still poorly understood. Here, with synthetic 3D fibre matrices of controlled alignment and stiffness, the authors report that cells in stiff matrices move slowly and continuously, but in softer, deformable matrices cells can rapidly slingshot forward via stre...

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Main Authors:	William Y. Wang, Christopher D. Davidson, Daphne Lin, Brendon M. Baker
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/b6d65b2bec4e4f619c3788aad89acbbf
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spelling	oai:doaj.org-article:b6d65b2bec4e4f619c3788aad89acbbf2021-12-02T17:31:53ZActomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration10.1038/s41467-019-09121-02041-1723https://doaj.org/article/b6d65b2bec4e4f619c3788aad89acbbf2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09121-0https://doaj.org/toc/2041-1723How cells migrate in fibrous tissues is still poorly understood. Here, with synthetic 3D fibre matrices of controlled alignment and stiffness, the authors report that cells in stiff matrices move slowly and continuously, but in softer, deformable matrices cells can rapidly slingshot forward via stretch and recoil of matrix fibres.William Y. WangChristopher D. DavidsonDaphne LinBrendon M. BakerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William Y. Wang Christopher D. Davidson Daphne Lin Brendon M. Baker Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
description	How cells migrate in fibrous tissues is still poorly understood. Here, with synthetic 3D fibre matrices of controlled alignment and stiffness, the authors report that cells in stiff matrices move slowly and continuously, but in softer, deformable matrices cells can rapidly slingshot forward via stretch and recoil of matrix fibres.
format	article
author	William Y. Wang Christopher D. Davidson Daphne Lin Brendon M. Baker
author_facet	William Y. Wang Christopher D. Davidson Daphne Lin Brendon M. Baker
author_sort	William Y. Wang
title	Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
title_short	Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
title_full	Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
title_fullStr	Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
title_full_unstemmed	Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
title_sort	actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b6d65b2bec4e4f619c3788aad89acbbf
work_keys_str_mv	AT williamywang actomyosincontractilitydependentmatrixstretchandrecoilinducesrapidcellmigration AT christopherddavidson actomyosincontractilitydependentmatrixstretchandrecoilinducesrapidcellmigration AT daphnelin actomyosincontractilitydependentmatrixstretchandrecoilinducesrapidcellmigration AT brendonmbaker actomyosincontractilitydependentmatrixstretchandrecoilinducesrapidcellmigration
_version_	1718380451691757568

Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

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