USP21 prevents the generation of T-helper-1-like Treg cells

The immunosuppressive role of regulatory T (Treg) cells largely depends on their virtue of expressing the transcription factor FOXP3. Here the authors show that the E3 deubiquitinase USP21 stabilizes FOXP3 by mediating its deubiquitination and helps to maintain the expression of Treg signature genes...

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Autores principales:	Yangyang Li, Yue Lu, Shuaiwei Wang, Zhijun Han, Fuxiang Zhu, Yingmeng Ni, Rui Liang, Yan Zhang, Qibin Leng, Gang Wei, Guochao Shi, Ruihong Zhu, Dan Li, Haikun Wang, Song Guo Zheng, Hongxi Xu, Andy Tsun, Bin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6d6ab99c2dc46daa7334b47a2595c89
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spelling	oai:doaj.org-article:b6d6ab99c2dc46daa7334b47a2595c892021-12-02T16:50:15ZUSP21 prevents the generation of T-helper-1-like Treg cells10.1038/ncomms135592041-1723https://doaj.org/article/b6d6ab99c2dc46daa7334b47a2595c892016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13559https://doaj.org/toc/2041-1723The immunosuppressive role of regulatory T (Treg) cells largely depends on their virtue of expressing the transcription factor FOXP3. Here the authors show that the E3 deubiquitinase USP21 stabilizes FOXP3 by mediating its deubiquitination and helps to maintain the expression of Treg signature genes and Treg lineage stability in mice.Yangyang LiYue LuShuaiwei WangZhijun HanFuxiang ZhuYingmeng NiRui LiangYan ZhangQibin LengGang WeiGuochao ShiRuihong ZhuDan LiHaikun WangSong Guo ZhengHongxi XuAndy TsunBin LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yangyang Li Yue Lu Shuaiwei Wang Zhijun Han Fuxiang Zhu Yingmeng Ni Rui Liang Yan Zhang Qibin Leng Gang Wei Guochao Shi Ruihong Zhu Dan Li Haikun Wang Song Guo Zheng Hongxi Xu Andy Tsun Bin Li USP21 prevents the generation of T-helper-1-like Treg cells
description	The immunosuppressive role of regulatory T (Treg) cells largely depends on their virtue of expressing the transcription factor FOXP3. Here the authors show that the E3 deubiquitinase USP21 stabilizes FOXP3 by mediating its deubiquitination and helps to maintain the expression of Treg signature genes and Treg lineage stability in mice.
format	article
author	Yangyang Li Yue Lu Shuaiwei Wang Zhijun Han Fuxiang Zhu Yingmeng Ni Rui Liang Yan Zhang Qibin Leng Gang Wei Guochao Shi Ruihong Zhu Dan Li Haikun Wang Song Guo Zheng Hongxi Xu Andy Tsun Bin Li
author_facet	Yangyang Li Yue Lu Shuaiwei Wang Zhijun Han Fuxiang Zhu Yingmeng Ni Rui Liang Yan Zhang Qibin Leng Gang Wei Guochao Shi Ruihong Zhu Dan Li Haikun Wang Song Guo Zheng Hongxi Xu Andy Tsun Bin Li
author_sort	Yangyang Li
title	USP21 prevents the generation of T-helper-1-like Treg cells
title_short	USP21 prevents the generation of T-helper-1-like Treg cells
title_full	USP21 prevents the generation of T-helper-1-like Treg cells
title_fullStr	USP21 prevents the generation of T-helper-1-like Treg cells
title_full_unstemmed	USP21 prevents the generation of T-helper-1-like Treg cells
title_sort	usp21 prevents the generation of t-helper-1-like treg cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b6d6ab99c2dc46daa7334b47a2595c89
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USP21 prevents the generation of T-helper-1-like Treg cells

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