Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy

Background: Acute pancreatitis in pregnancy is a rare but highly life-threatening gestational and perinatal disease.Objective: This study aimed to identify the risk factors for fetal death and acute pancreatitis severity.Methods: This retrospective cohort study enrolled patients with acute pancreati...

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Autores principales:	Xiaolei Shi, Yuepeng Hu, Na Pu, Guofu Zhang, Jingzhu Zhang, Jing Zhou, Bo Ye, Gang Li, Lu Ke, Yuxiu Liu, Qi Yang, Zhihui Tong, Weiqin Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acute pancreatitis in pregnancy hypertriglyceridemia fetal intrauterine death ARDS gestational week Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/b6d83fdc6e024d16a90acc6646e598e9
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spelling	oai:doaj.org-article:b6d83fdc6e024d16a90acc6646e598e92021-12-02T10:11:32ZRisk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy2296-236010.3389/fped.2021.769400https://doaj.org/article/b6d83fdc6e024d16a90acc6646e598e92021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.769400/fullhttps://doaj.org/toc/2296-2360Background: Acute pancreatitis in pregnancy is a rare but highly life-threatening gestational and perinatal disease.Objective: This study aimed to identify the risk factors for fetal death and acute pancreatitis severity.Methods: This retrospective cohort study enrolled patients with acute pancreatitis in pregnancy in our center from January 1, 2012, to August 1, 2020, and classified them according to two clinical endpoints, fetal outcome and disease severity. The groups were examined and compared according to gestational week, etiology, gravidity and parity, complications in pre- and post-delivery, and medical history. Logistic regression analysis was performed to identify the independent risk factors for fetal death and acute pancreatitis severity.Results: Of the 90 enrolled patients, 28 (31.1%) had fetal death and 43 (47.8%) had severe acute pancreatitis. Logistic regression analysis showed that pre-delivery acute respiratory distress syndrome (OR, 5.8; 95% CI, 1.5–22.4; p = 0.010) and gestational week (OR, 0.9; 95% CI, 0.8–1.0; p = 0.011) were risk factors for fetal death. Gestation week (OR, 1.2; 95% CI, 1.1–1.3; p = 0.003) and fetal intrauterine death (OR, 5.9; 95% CI, 1.8–19.4; p = 0.003) were risk factors for severe acute pancreatitis.Conclusions: Pre-delivery acute respiratory distress syndrome and gestational week were independent risk factors for fetal death. Fetal intrauterine death and gestational week were independent risk factors for severe acute pancreatitis.Xiaolei ShiYuepeng HuNa PuGuofu ZhangJingzhu ZhangJing ZhouBo YeGang LiLu KeYuxiu LiuQi YangZhihui TongWeiqin LiFrontiers Media S.A.articleacute pancreatitis in pregnancyhypertriglyceridemiafetal intrauterine deathARDSgestational weekPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute pancreatitis in pregnancy hypertriglyceridemia fetal intrauterine death ARDS gestational week Pediatrics RJ1-570
spellingShingle	acute pancreatitis in pregnancy hypertriglyceridemia fetal intrauterine death ARDS gestational week Pediatrics RJ1-570 Xiaolei Shi Yuepeng Hu Na Pu Guofu Zhang Jingzhu Zhang Jing Zhou Bo Ye Gang Li Lu Ke Yuxiu Liu Qi Yang Zhihui Tong Weiqin Li Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy
description	Background: Acute pancreatitis in pregnancy is a rare but highly life-threatening gestational and perinatal disease.Objective: This study aimed to identify the risk factors for fetal death and acute pancreatitis severity.Methods: This retrospective cohort study enrolled patients with acute pancreatitis in pregnancy in our center from January 1, 2012, to August 1, 2020, and classified them according to two clinical endpoints, fetal outcome and disease severity. The groups were examined and compared according to gestational week, etiology, gravidity and parity, complications in pre- and post-delivery, and medical history. Logistic regression analysis was performed to identify the independent risk factors for fetal death and acute pancreatitis severity.Results: Of the 90 enrolled patients, 28 (31.1%) had fetal death and 43 (47.8%) had severe acute pancreatitis. Logistic regression analysis showed that pre-delivery acute respiratory distress syndrome (OR, 5.8; 95% CI, 1.5–22.4; p = 0.010) and gestational week (OR, 0.9; 95% CI, 0.8–1.0; p = 0.011) were risk factors for fetal death. Gestation week (OR, 1.2; 95% CI, 1.1–1.3; p = 0.003) and fetal intrauterine death (OR, 5.9; 95% CI, 1.8–19.4; p = 0.003) were risk factors for severe acute pancreatitis.Conclusions: Pre-delivery acute respiratory distress syndrome and gestational week were independent risk factors for fetal death. Fetal intrauterine death and gestational week were independent risk factors for severe acute pancreatitis.
format	article
author	Xiaolei Shi Yuepeng Hu Na Pu Guofu Zhang Jingzhu Zhang Jing Zhou Bo Ye Gang Li Lu Ke Yuxiu Liu Qi Yang Zhihui Tong Weiqin Li
author_facet	Xiaolei Shi Yuepeng Hu Na Pu Guofu Zhang Jingzhu Zhang Jing Zhou Bo Ye Gang Li Lu Ke Yuxiu Liu Qi Yang Zhihui Tong Weiqin Li
author_sort	Xiaolei Shi
title	Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy
title_short	Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy
title_full	Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy
title_fullStr	Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy
title_full_unstemmed	Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy
title_sort	risk factors for fetal death and maternal ap severity in acute pancreatitis in pregnancy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b6d83fdc6e024d16a90acc6646e598e9
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Risk Factors for Fetal Death and Maternal AP Severity in Acute Pancreatitis in Pregnancy

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