Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus

Background: Viral pneumonia is one of the most serious respiratory diseases, and multicomponent traditional Chinese medicines have been applied in the management of infected patients. As a representative TCM, HouYanQing (HYQ) oral liquid shows antiviral activity. However, the unclear mechanisms, as...

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Autores principales:	Junying Wei, Jianhui Sun, Jiawei Zeng, Enhui Ji, Jing Xu, Chunyu Tang, Hairu Huo, Yi Zhang, Hongmei Li, Hongjun Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pneumonia precise medicine multicomponent drug proteomics houyanqing oral liquid Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b6d85b1016c9443280deb3843640f9d8
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spelling	oai:doaj.org-article:b6d85b1016c9443280deb3843640f9d82021-11-18T05:08:08ZPrecise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus1663-981210.3389/fphar.2021.604009https://doaj.org/article/b6d85b1016c9443280deb3843640f9d82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.604009/fullhttps://doaj.org/toc/1663-9812Background: Viral pneumonia is one of the most serious respiratory diseases, and multicomponent traditional Chinese medicines have been applied in the management of infected patients. As a representative TCM, HouYanQing (HYQ) oral liquid shows antiviral activity. However, the unclear mechanisms, as well as the ambiguous clinical effects, limit widespread application of this treatment. Therefore, in this study, a proteomics-based approach was utilized to precisely investigate its efficacy.Methods: Based on the efficacy evaluation of HYQ in a mouse model of pneumonia caused by influenza A virus (H1N1) and the subsequent proteomics analysis, specific signatures regulated by HYQ treatment of viral pneumonia were identified.Results: Experimental verifications indicate that HYQ may show distinctive effects in viral pneumonia patients, such as elevated galectin-3-binding protein and glutathione peroxidase 3 levels.Conclusion: This study provides a precise investigation of the efficacy of a multicomponent drug against viral pneumonia and offers a promising alternative for personalized management of viral pneumonia.Junying WeiJianhui SunJiawei ZengEnhui JiJing XuChunyu TangHairu HuoYi ZhangHongmei LiHongjun YangFrontiers Media S.A.articlepneumoniaprecise medicinemulticomponent drugproteomicshouyanqing oral liquidTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pneumonia precise medicine multicomponent drug proteomics houyanqing oral liquid Therapeutics. Pharmacology RM1-950
spellingShingle	pneumonia precise medicine multicomponent drug proteomics houyanqing oral liquid Therapeutics. Pharmacology RM1-950 Junying Wei Jianhui Sun Jiawei Zeng Enhui Ji Jing Xu Chunyu Tang Hairu Huo Yi Zhang Hongmei Li Hongjun Yang Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus
description	Background: Viral pneumonia is one of the most serious respiratory diseases, and multicomponent traditional Chinese medicines have been applied in the management of infected patients. As a representative TCM, HouYanQing (HYQ) oral liquid shows antiviral activity. However, the unclear mechanisms, as well as the ambiguous clinical effects, limit widespread application of this treatment. Therefore, in this study, a proteomics-based approach was utilized to precisely investigate its efficacy.Methods: Based on the efficacy evaluation of HYQ in a mouse model of pneumonia caused by influenza A virus (H1N1) and the subsequent proteomics analysis, specific signatures regulated by HYQ treatment of viral pneumonia were identified.Results: Experimental verifications indicate that HYQ may show distinctive effects in viral pneumonia patients, such as elevated galectin-3-binding protein and glutathione peroxidase 3 levels.Conclusion: This study provides a precise investigation of the efficacy of a multicomponent drug against viral pneumonia and offers a promising alternative for personalized management of viral pneumonia.
format	article
author	Junying Wei Jianhui Sun Jiawei Zeng Enhui Ji Jing Xu Chunyu Tang Hairu Huo Yi Zhang Hongmei Li Hongjun Yang
author_facet	Junying Wei Jianhui Sun Jiawei Zeng Enhui Ji Jing Xu Chunyu Tang Hairu Huo Yi Zhang Hongmei Li Hongjun Yang
author_sort	Junying Wei
title	Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus
title_short	Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus
title_full	Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus
title_fullStr	Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus
title_full_unstemmed	Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus
title_sort	precise investigation of the efficacy of multicomponent drugs against pneumonia infected with influenza virus
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b6d85b1016c9443280deb3843640f9d8
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Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus

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