Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes

Abstract Background To evaluate the accuracy and safety of micro radial and arcuate keratotomy incisions constructed by a femtosecond laser system with a curved contact patient interface in porcine eyes. Methods Partial thickness micro radial and arcuate keratotomy incisions were constructed in porc...

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Autores principales:	E. Valas Teuma, Frank A. Bucci, Raman Bedi, Gary Gray, Mark Packer
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Partial thickness micro radial and arcuate keratotomy incisions Curved contact patient interface Micro radial keratotomy Arcuate keratotomy Femtosecond laser system with curved contact interface LENSAR femtosecond laser system Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b6dd956ffc8b49dc91ba4f90fa62b359
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spelling	oai:doaj.org-article:b6dd956ffc8b49dc91ba4f90fa62b3592021-12-05T12:16:34ZAccuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes10.1186/s40662-021-00268-w2326-0254https://doaj.org/article/b6dd956ffc8b49dc91ba4f90fa62b3592021-12-01T00:00:00Zhttps://doi.org/10.1186/s40662-021-00268-whttps://doaj.org/toc/2326-0254Abstract Background To evaluate the accuracy and safety of micro radial and arcuate keratotomy incisions constructed by a femtosecond laser system with a curved contact patient interface in porcine eyes. Methods Partial thickness micro radial and arcuate keratotomy incisions were constructed in porcine eyes with a femtosecond laser system and evaluated for precision of depth, quality, and consistency. Optical coherence tomography was used to determine the accuracy and precision of incision depth. Corneal endothelial safety was assessed by a fluorescent live/dead cell viability assay to demonstrate laser-induced endothelial cell loss. Quality was evaluated by ease of opening and examination of interfaces. Results In two micro radial incision groups, intended incision depths of 50% and 80% resulted in mean achieved depths of 50.01% and 77.69%, respectively. In three arcuate incision groups, intended incision depths of 80%, 600 μm or 100 μm residual uncut bed thickness resulted in mean achieved depths of 80.16%, 603.03 μm and residual bed of 115 μm, respectively. No loss of endothelial cell density occurred when the residual corneal bed was maintained at a minimum of 85–116 µm. The incisions were easy to open, and interfaces were smooth. Conclusions A femtosecond laser system with curved contact interface created precise and reproducible micro radial and arcuate keratotomy incisions. Accuracy and precision of the incision depth and preservation of endothelial cell density demonstrated the effectiveness and safety of the system.E. Valas TeumaFrank A. BucciRaman BediGary GrayMark PackerBMCarticlePartial thickness micro radial and arcuate keratotomy incisionsCurved contact patient interfaceMicro radial keratotomyArcuate keratotomyFemtosecond laser system with curved contact interfaceLENSAR femtosecond laser systemOphthalmologyRE1-994ENEye and Vision, Vol 8, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Partial thickness micro radial and arcuate keratotomy incisions Curved contact patient interface Micro radial keratotomy Arcuate keratotomy Femtosecond laser system with curved contact interface LENSAR femtosecond laser system Ophthalmology RE1-994
spellingShingle	Partial thickness micro radial and arcuate keratotomy incisions Curved contact patient interface Micro radial keratotomy Arcuate keratotomy Femtosecond laser system with curved contact interface LENSAR femtosecond laser system Ophthalmology RE1-994 E. Valas Teuma Frank A. Bucci Raman Bedi Gary Gray Mark Packer Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes
description	Abstract Background To evaluate the accuracy and safety of micro radial and arcuate keratotomy incisions constructed by a femtosecond laser system with a curved contact patient interface in porcine eyes. Methods Partial thickness micro radial and arcuate keratotomy incisions were constructed in porcine eyes with a femtosecond laser system and evaluated for precision of depth, quality, and consistency. Optical coherence tomography was used to determine the accuracy and precision of incision depth. Corneal endothelial safety was assessed by a fluorescent live/dead cell viability assay to demonstrate laser-induced endothelial cell loss. Quality was evaluated by ease of opening and examination of interfaces. Results In two micro radial incision groups, intended incision depths of 50% and 80% resulted in mean achieved depths of 50.01% and 77.69%, respectively. In three arcuate incision groups, intended incision depths of 80%, 600 μm or 100 μm residual uncut bed thickness resulted in mean achieved depths of 80.16%, 603.03 μm and residual bed of 115 μm, respectively. No loss of endothelial cell density occurred when the residual corneal bed was maintained at a minimum of 85–116 µm. The incisions were easy to open, and interfaces were smooth. Conclusions A femtosecond laser system with curved contact interface created precise and reproducible micro radial and arcuate keratotomy incisions. Accuracy and precision of the incision depth and preservation of endothelial cell density demonstrated the effectiveness and safety of the system.
format	article
author	E. Valas Teuma Frank A. Bucci Raman Bedi Gary Gray Mark Packer
author_facet	E. Valas Teuma Frank A. Bucci Raman Bedi Gary Gray Mark Packer
author_sort	E. Valas Teuma
title	Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes
title_short	Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes
title_full	Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes
title_fullStr	Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes
title_full_unstemmed	Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes
title_sort	accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b6dd956ffc8b49dc91ba4f90fa62b359
work_keys_str_mv	AT evalasteuma accuracyandsafetyofpartialthicknessfemtosecondlaserradialandarcuatekeratotomyincisionsinporcineeyes AT frankabucci accuracyandsafetyofpartialthicknessfemtosecondlaserradialandarcuatekeratotomyincisionsinporcineeyes AT ramanbedi accuracyandsafetyofpartialthicknessfemtosecondlaserradialandarcuatekeratotomyincisionsinporcineeyes AT garygray accuracyandsafetyofpartialthicknessfemtosecondlaserradialandarcuatekeratotomyincisionsinporcineeyes AT markpacker accuracyandsafetyofpartialthicknessfemtosecondlaserradialandarcuatekeratotomyincisionsinporcineeyes
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Accuracy and safety of partial thickness femtosecond laser radial and arcuate keratotomy incisions in porcine eyes

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