MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression

Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic activity in clear cell renal carcinomas.

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Autores principales:	Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6df3eea370a40a0932a4398891238b5
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spelling	oai:doaj.org-article:b6df3eea370a40a0932a4398891238b52021-12-02T14:39:58ZMERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression10.1038/s41467-019-09233-72041-1723https://doaj.org/article/b6df3eea370a40a0932a4398891238b52019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09233-7https://doaj.org/toc/2041-1723Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic activity in clear cell renal carcinomas.Yao JiangYanqiong ZhangJanet Y. LeungCheng FanKonstantin I. PopovSiyuan SuJiayi QianXiaodong WangAlisha HoltzhausenEric UbilYang XiangIan DavisNikolay V. DokholyanGang WuCharles M. PerouWilliam Y. KimH. Shelton EarpPengda LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao Jiang Yanqiong Zhang Janet Y. Leung Cheng Fan Konstantin I. Popov Siyuan Su Jiayi Qian Xiaodong Wang Alisha Holtzhausen Eric Ubil Yang Xiang Ian Davis Nikolay V. Dokholyan Gang Wu Charles M. Perou William Y. Kim H. Shelton Earp Pengda Liu MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
description	Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic activity in clear cell renal carcinomas.
format	article
author	Yao Jiang Yanqiong Zhang Janet Y. Leung Cheng Fan Konstantin I. Popov Siyuan Su Jiayi Qian Xiaodong Wang Alisha Holtzhausen Eric Ubil Yang Xiang Ian Davis Nikolay V. Dokholyan Gang Wu Charles M. Perou William Y. Kim H. Shelton Earp Pengda Liu
author_facet	Yao Jiang Yanqiong Zhang Janet Y. Leung Cheng Fan Konstantin I. Popov Siyuan Su Jiayi Qian Xiaodong Wang Alisha Holtzhausen Eric Ubil Yang Xiang Ian Davis Nikolay V. Dokholyan Gang Wu Charles M. Perou William Y. Kim H. Shelton Earp Pengda Liu
author_sort	Yao Jiang
title	MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
title_short	MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
title_full	MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
title_fullStr	MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
title_full_unstemmed	MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression
title_sort	mertk mediated novel site akt phosphorylation alleviates sav1 suppression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b6df3eea370a40a0932a4398891238b5
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MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression

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