Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

Li, Chen, Vong, Zhao et al. show that glucagon-like peptide-1 receptor agonist reverses transcriptomic aging signatures in mouse glial and neurovascular cells. This study suggests that glucagon-like peptide-1 receptor agonists may be considered as a therapeutic option for patients at risk of age-rel...

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Autores principales:	Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Ip, Yun Kwok Wing, Hei-Ming Lai, Vincent C. T. Mok, Ho Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b6e03838a0f54cd39260f2154383d3c8
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spelling	oai:doaj.org-article:b6e03838a0f54cd39260f2154383d3c82021-12-02T18:25:02ZSystemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner10.1038/s42003-021-02208-92399-3642https://doaj.org/article/b6e03838a0f54cd39260f2154383d3c82021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02208-9https://doaj.org/toc/2399-3642Li, Chen, Vong, Zhao et al. show that glucagon-like peptide-1 receptor agonist reverses transcriptomic aging signatures in mouse glial and neurovascular cells. This study suggests that glucagon-like peptide-1 receptor agonists may be considered as a therapeutic option for patients at risk of age-related neurodegeneration.Zhongqi LiXinyi ChenJoaquim S. L. VongLei ZhaoJunzhe HuangLeo Y. C. YanBonaventure IpYun Kwok WingHei-Ming LaiVincent C. T. MokHo KoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Zhongqi Li Xinyi Chen Joaquim S. L. Vong Lei Zhao Junzhe Huang Leo Y. C. Yan Bonaventure Ip Yun Kwok Wing Hei-Ming Lai Vincent C. T. Mok Ho Ko Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
description	Li, Chen, Vong, Zhao et al. show that glucagon-like peptide-1 receptor agonist reverses transcriptomic aging signatures in mouse glial and neurovascular cells. This study suggests that glucagon-like peptide-1 receptor agonists may be considered as a therapeutic option for patients at risk of age-related neurodegeneration.
format	article
author	Zhongqi Li Xinyi Chen Joaquim S. L. Vong Lei Zhao Junzhe Huang Leo Y. C. Yan Bonaventure Ip Yun Kwok Wing Hei-Ming Lai Vincent C. T. Mok Ho Ko
author_facet	Zhongqi Li Xinyi Chen Joaquim S. L. Vong Lei Zhao Junzhe Huang Leo Y. C. Yan Bonaventure Ip Yun Kwok Wing Hei-Ming Lai Vincent C. T. Mok Ho Ko
author_sort	Zhongqi Li
title	Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
title_short	Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
title_full	Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
title_fullStr	Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
title_full_unstemmed	Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
title_sort	systemic glp-1r agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6e03838a0f54cd39260f2154383d3c8
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Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

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