Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection

The Southern African HIV Clinicians Society published its first set of oral pre-exposure prophylaxis (PrEP) guidelines in June 2012 for men who have sex with men (MSM) who are at risk of HIV infection. With the flurry of data that has been generated in PrEP clinical research since the first guidelin...

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Autores principales:	L. Bekker, K. Rebe, F. Venter, G. Maartens, M. Moorhouse, F. Conradie, C. Wallis, V. Black, B. Harley, R. Eakles
Formato:	article
Lenguaje:	EN
Publicado:	AOSIS 2016
Materias:	southern african guidelines safe use pre-exposure prophylaxis hiv-1 infection Medicine R
Acceso en línea:	https://doaj.org/article/b6e06dc23d0741a893a05e60878352e7
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spelling	oai:doaj.org-article:b6e06dc23d0741a893a05e60878352e72021-11-24T07:44:19ZSouthern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection2078-61902078-620410.4102/safp.v58i5.4562https://doaj.org/article/b6e06dc23d0741a893a05e60878352e72016-11-01T00:00:00Zhttps://safpj.co.za/index.php/safpj/article/view/4562https://doaj.org/toc/2078-6190https://doaj.org/toc/2078-6204The Southern African HIV Clinicians Society published its first set of oral pre-exposure prophylaxis (PrEP) guidelines in June 2012 for men who have sex with men (MSM) who are at risk of HIV infection. With the flurry of data that has been generated in PrEP clinical research since the first guideline, it became evident that there was a need to revise and expand the PrEP guidelines with new evidence of safety and efficacy of PrEP in several populations, including MSM, transgender persons, heterosexual men and women, HIV-serodiscordant couples and people who inject drugs. This need is particularly relevant following the World Health Organization (WHO) Consolidated Treatment Guidelines released in September 2015. These guidelines advise that PrEP is a highly effective, safe, biomedical option for HIV prevention that can be incorporated with other combination prevention strategies in Southern Africa, given the high prevalence of HIV in the region. PrEP should be tailored to populations at highest risk of HIV acquisition, whilst further data from studies in the region accrue to guide optimal deployment to realise the greatest impact regionally. PrEP may be used intermittently during periods of perceived HIV acquisition risk, rather than continually and lifelong, as is the case with antiretroviral treatment. Recognition and accurate measurement of potential risk in individuals and populations also warrants discussion, but are not extensively covered in these guidelines.L. BekkerK. RebeF. VenterG. MaartensM. MoorhouseF. ConradieC. WallisV. BlackB. HarleyR. EaklesAOSISarticlesouthern african guidelinessafe usepre-exposure prophylaxishiv-1 infectionMedicineRENSouth African Family Practice, Vol 58, Iss 5, Pp 6-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	southern african guidelines safe use pre-exposure prophylaxis hiv-1 infection Medicine R
spellingShingle	southern african guidelines safe use pre-exposure prophylaxis hiv-1 infection Medicine R L. Bekker K. Rebe F. Venter G. Maartens M. Moorhouse F. Conradie C. Wallis V. Black B. Harley R. Eakles Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection
description	The Southern African HIV Clinicians Society published its first set of oral pre-exposure prophylaxis (PrEP) guidelines in June 2012 for men who have sex with men (MSM) who are at risk of HIV infection. With the flurry of data that has been generated in PrEP clinical research since the first guideline, it became evident that there was a need to revise and expand the PrEP guidelines with new evidence of safety and efficacy of PrEP in several populations, including MSM, transgender persons, heterosexual men and women, HIV-serodiscordant couples and people who inject drugs. This need is particularly relevant following the World Health Organization (WHO) Consolidated Treatment Guidelines released in September 2015. These guidelines advise that PrEP is a highly effective, safe, biomedical option for HIV prevention that can be incorporated with other combination prevention strategies in Southern Africa, given the high prevalence of HIV in the region. PrEP should be tailored to populations at highest risk of HIV acquisition, whilst further data from studies in the region accrue to guide optimal deployment to realise the greatest impact regionally. PrEP may be used intermittently during periods of perceived HIV acquisition risk, rather than continually and lifelong, as is the case with antiretroviral treatment. Recognition and accurate measurement of potential risk in individuals and populations also warrants discussion, but are not extensively covered in these guidelines.
format	article
author	L. Bekker K. Rebe F. Venter G. Maartens M. Moorhouse F. Conradie C. Wallis V. Black B. Harley R. Eakles
author_facet	L. Bekker K. Rebe F. Venter G. Maartens M. Moorhouse F. Conradie C. Wallis V. Black B. Harley R. Eakles
author_sort	L. Bekker
title	Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection
title_short	Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection
title_full	Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection
title_fullStr	Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection
title_full_unstemmed	Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection
title_sort	southern african guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring hiv-1 infection
publisher	AOSIS
publishDate	2016
url	https://doaj.org/article/b6e06dc23d0741a893a05e60878352e7
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Southern African guidelines on the safe use of pre-exposure prophylaxis in persons at risk of acquiring HIV-1 infection

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