Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography

The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of TLC for radiochemical purity testing system that is faster and more practical. Two-system method of TLC for r...

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Autores principales:	Maskur Maskur, Enny Lestari, Amal Rezka Putra, Dede Kurniasih, Endang Sarmini, Yayan Tahyan, Adang Hardi Gunawan, Arni Aries
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2019
Materias:	radiochemical purity 99mtc-dtpa 99mtc one-system of tlc two-system of tlc Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b6e3e1e6f94d4657add5da45c5e72060
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spelling	oai:doaj.org-article:b6e3e1e6f94d4657add5da45c5e720602021-12-02T13:24:22ZDetermination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography2302-46902302-4690https://doaj.org/article/b6e3e1e6f94d4657add5da45c5e720602019-06-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/461/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2302-4690The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of TLC for radiochemical purity testing system that is faster and more practical. Two-system method of TLC for radiochemical purity testing uses mobile phase of methyl ethyl ketone as an A and 0.9% sodium chloride solution as a B. One-system method uses the mobile phase of a mixture solution of acetone and 0.9% sodium chloride. In this study, the determination of radiochemical purity of the one-system of TLC has been successfully developed using the Whatman-1 paper stationary phase and the mixed mobile phase between acetone and 0.9% sodium chloride solution. The mobile phase of acetone: 0.9% sodium chloride with a ratio of 9:1 shows the most optimum results. This phase can separate 99mTc-DTPA (Rf = 0.4-0.6) from 99mTcO4- (Rf = 0.9-1.0) and 99mTcO2 (Rf = 0.0-0.1) as radiochemical impurities. This result shows that the one-system of TLC method can be used for radiochemical purity testing of 99mTc-DTPA radiopharmaceutical kits. This method can completely separate the product compound (99mTc-DTPA) from its impurities (99mTcO2 and 99mTcO4-).Maskur MaskurEnny LestariAmal Rezka PutraDede KurniasihEndang SarminiYayan TahyanAdang Hardi GunawanArni AriesUniversity of Brawijayaarticleradiochemical purity99mtc-dtpa99mtcone-system of tlctwo-system of tlcChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 8, Iss 2, Pp 109-116 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiochemical purity 99mtc-dtpa 99mtc one-system of tlc two-system of tlc Chemistry QD1-999
spellingShingle	radiochemical purity 99mtc-dtpa 99mtc one-system of tlc two-system of tlc Chemistry QD1-999 Maskur Maskur Enny Lestari Amal Rezka Putra Dede Kurniasih Endang Sarmini Yayan Tahyan Adang Hardi Gunawan Arni Aries Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography
description	The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of TLC for radiochemical purity testing system that is faster and more practical. Two-system method of TLC for radiochemical purity testing uses mobile phase of methyl ethyl ketone as an A and 0.9% sodium chloride solution as a B. One-system method uses the mobile phase of a mixture solution of acetone and 0.9% sodium chloride. In this study, the determination of radiochemical purity of the one-system of TLC has been successfully developed using the Whatman-1 paper stationary phase and the mixed mobile phase between acetone and 0.9% sodium chloride solution. The mobile phase of acetone: 0.9% sodium chloride with a ratio of 9:1 shows the most optimum results. This phase can separate 99mTc-DTPA (Rf = 0.4-0.6) from 99mTcO4- (Rf = 0.9-1.0) and 99mTcO2 (Rf = 0.0-0.1) as radiochemical impurities. This result shows that the one-system of TLC method can be used for radiochemical purity testing of 99mTc-DTPA radiopharmaceutical kits. This method can completely separate the product compound (99mTc-DTPA) from its impurities (99mTcO2 and 99mTcO4-).
format	article
author	Maskur Maskur Enny Lestari Amal Rezka Putra Dede Kurniasih Endang Sarmini Yayan Tahyan Adang Hardi Gunawan Arni Aries
author_facet	Maskur Maskur Enny Lestari Amal Rezka Putra Dede Kurniasih Endang Sarmini Yayan Tahyan Adang Hardi Gunawan Arni Aries
author_sort	Maskur Maskur
title	Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography
title_short	Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography
title_full	Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography
title_fullStr	Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography
title_full_unstemmed	Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography
title_sort	determination of radiochemical purity of 99mtc-dtpa using one-system method of paper chromatography
publisher	University of Brawijaya
publishDate	2019
url	https://doaj.org/article/b6e3e1e6f94d4657add5da45c5e72060
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Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography

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