STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to ant...

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Autores principales:	Jung-Mao Hsu, Weiya Xia, Yi-Hsin Hsu, Li-Chuan Chan, Wen-Hsuan Yu, Jong-Ho Cha, Chun-Te Chen, Hsin-Wei Liao, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L. Hsu, Chia-Wei Li, Seung-Oe Lim, Shih-Shin Chang, Yi-Chun Chen, Guo-xin Ren, Mien-Chie Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6e5e0697fa048aeb6392035c75e7d85
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:b6e5e0697fa048aeb6392035c75e7d852021-12-02T17:31:14ZSTT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion10.1038/s41467-018-04313-62041-1723https://doaj.org/article/b6e5e0697fa048aeb6392035c75e7d852018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04313-6https://doaj.org/toc/2041-1723PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to anti-Tim3-therapy.Jung-Mao HsuWeiya XiaYi-Hsin HsuLi-Chuan ChanWen-Hsuan YuJong-Ho ChaChun-Te ChenHsin-Wei LiaoChu-Wei KuoKay-Hooi KhooJennifer L. HsuChia-Wei LiSeung-Oe LimShih-Shin ChangYi-Chun ChenGuo-xin RenMien-Chie HungNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Mao Hsu Weiya Xia Yi-Hsin Hsu Li-Chuan Chan Wen-Hsuan Yu Jong-Ho Cha Chun-Te Chen Hsin-Wei Liao Chu-Wei Kuo Kay-Hooi Khoo Jennifer L. Hsu Chia-Wei Li Seung-Oe Lim Shih-Shin Chang Yi-Chun Chen Guo-xin Ren Mien-Chie Hung STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
description	PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to anti-Tim3-therapy.
format	article
author	Jung-Mao Hsu Weiya Xia Yi-Hsin Hsu Li-Chuan Chan Wen-Hsuan Yu Jong-Ho Cha Chun-Te Chen Hsin-Wei Liao Chu-Wei Kuo Kay-Hooi Khoo Jennifer L. Hsu Chia-Wei Li Seung-Oe Lim Shih-Shin Chang Yi-Chun Chen Guo-xin Ren Mien-Chie Hung
author_facet	Jung-Mao Hsu Weiya Xia Yi-Hsin Hsu Li-Chuan Chan Wen-Hsuan Yu Jong-Ho Cha Chun-Te Chen Hsin-Wei Liao Chu-Wei Kuo Kay-Hooi Khoo Jennifer L. Hsu Chia-Wei Li Seung-Oe Lim Shih-Shin Chang Yi-Chun Chen Guo-xin Ren Mien-Chie Hung
author_sort	Jung-Mao Hsu
title	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_short	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_full	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_fullStr	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_full_unstemmed	STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
title_sort	stt3-dependent pd-l1 accumulation on cancer stem cells promotes immune evasion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b6e5e0697fa048aeb6392035c75e7d85
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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

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