Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia

Abstract Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective analysis of microbiological findings...

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Autores principales:	Mengistu Hailemariam, Tsegaye Alemayehu, Bereket Tadesse, Netsanete Nigussie, Asnakech Agegnehu, Techilo Habtemariam, Mulubrhan Ali, Enkosilassie Mitiku, Elshaday Azerefegne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6e60bc99d5e4d38ac65a1838d1fd9a2
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spelling	oai:doaj.org-article:b6e60bc99d5e4d38ac65a1838d1fd9a22021-12-02T19:16:18ZMajor bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia10.1038/s41598-021-99272-22045-2322https://doaj.org/article/b6e60bc99d5e4d38ac65a1838d1fd9a22021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99272-2https://doaj.org/toc/2045-2322Abstract Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective analysis of microbiological findings at the Hawassa public hospital. Secondary data were retrieved to assess the prevalence and level of drug resistance for the most common bacterial isolates from clinical samples processed at Hawassa University Comprehensive Specialized Hospital. Out of 1085 clinical samples processed in the microbiology laboratory, the prevalence of bacterial infection was 32.6%. Bacterial bloodstream infection was higher in children than in adults (OR, 4; 95% CI 1.8–14.6; p = 0.005). E. coli and K. pneumoniae were the commonest bacterial isolate both in children (36.8%, 26.3%) and in adults (33.3%, 26.7%) from the urine sample while, the leading bacteria identified from the CSF sample was P. aeruginosa, 37% in children and 43% in adult. In this study, all identified bacterial isolates were multi-drug resistant (MDR) ranging from 50 to 91%. The highest proportion of MDR was S. aureus 91.1 followed by K. pneumoniae 87.6%. Since the nationwide investigation of bacterial isolate, and drug resistance is rare in Ethiopia, a report from such type of local surveillance is highly useful to guide empirical therapy by providing awareness on the level resistance of isolates.Mengistu HailemariamTsegaye AlemayehuBereket TadesseNetsanete NigussieAsnakech AgegnehuTechilo HabtemariamMulubrhan AliEnkosilassie MitikuElshaday AzerefegneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengistu Hailemariam Tsegaye Alemayehu Bereket Tadesse Netsanete Nigussie Asnakech Agegnehu Techilo Habtemariam Mulubrhan Ali Enkosilassie Mitiku Elshaday Azerefegne Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia
description	Abstract Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective analysis of microbiological findings at the Hawassa public hospital. Secondary data were retrieved to assess the prevalence and level of drug resistance for the most common bacterial isolates from clinical samples processed at Hawassa University Comprehensive Specialized Hospital. Out of 1085 clinical samples processed in the microbiology laboratory, the prevalence of bacterial infection was 32.6%. Bacterial bloodstream infection was higher in children than in adults (OR, 4; 95% CI 1.8–14.6; p = 0.005). E. coli and K. pneumoniae were the commonest bacterial isolate both in children (36.8%, 26.3%) and in adults (33.3%, 26.7%) from the urine sample while, the leading bacteria identified from the CSF sample was P. aeruginosa, 37% in children and 43% in adult. In this study, all identified bacterial isolates were multi-drug resistant (MDR) ranging from 50 to 91%. The highest proportion of MDR was S. aureus 91.1 followed by K. pneumoniae 87.6%. Since the nationwide investigation of bacterial isolate, and drug resistance is rare in Ethiopia, a report from such type of local surveillance is highly useful to guide empirical therapy by providing awareness on the level resistance of isolates.
format	article
author	Mengistu Hailemariam Tsegaye Alemayehu Bereket Tadesse Netsanete Nigussie Asnakech Agegnehu Techilo Habtemariam Mulubrhan Ali Enkosilassie Mitiku Elshaday Azerefegne
author_facet	Mengistu Hailemariam Tsegaye Alemayehu Bereket Tadesse Netsanete Nigussie Asnakech Agegnehu Techilo Habtemariam Mulubrhan Ali Enkosilassie Mitiku Elshaday Azerefegne
author_sort	Mengistu Hailemariam
title	Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia
title_short	Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia
title_full	Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia
title_fullStr	Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia
title_full_unstemmed	Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia
title_sort	major bacterial isolate and antibiotic resistance from routine clinical samples in southern ethiopia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6e60bc99d5e4d38ac65a1838d1fd9a2
work_keys_str_mv	AT mengistuhailemariam majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT tsegayealemayehu majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT berekettadesse majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT netsanetenigussie majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT asnakechagegnehu majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT techilohabtemariam majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT mulubrhanali majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT enkosilassiemitiku majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia AT elshadayazerefegne majorbacterialisolateandantibioticresistancefromroutineclinicalsamplesinsouthernethiopia
_version_	1718376992374521856

Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia

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