The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients
Koji Nitta,1,2 Shiro Shimamoto,3 Ryotaro Wajima,2 Gaku Tachibana,2 Yutaro Yamada,1,2 Miyuki Domoto,1 Ryuji Takeda,4,5 Yoshinari Takahashi,6 Kazuhisa Sugiyama2 1Fukui-ken Saiseikai Hospital, Fukui, Japan; 2Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa,...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b6e64d27c80c49069c79dfd23dff7216 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b6e64d27c80c49069c79dfd23dff7216 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b6e64d27c80c49069c79dfd23dff72162021-12-02T08:39:04ZThe Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients1177-5483https://doaj.org/article/b6e64d27c80c49069c79dfd23dff72162020-01-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-brimonidine-01-on-disc-hemorrhage-in-primary-open-angle--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Koji Nitta,1,2 Shiro Shimamoto,3 Ryotaro Wajima,2 Gaku Tachibana,2 Yutaro Yamada,1,2 Miyuki Domoto,1 Ryuji Takeda,4,5 Yoshinari Takahashi,6 Kazuhisa Sugiyama2 1Fukui-ken Saiseikai Hospital, Fukui, Japan; 2Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan; 3Shimamoto Ophthalmology Clinic, Fukui, Japan; 4Department of Nutritional Sciences for Well-Being, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Osaka, Japan; 5Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, Nara, Japan; 6Inary Co., Ltd., Tokyo, JapanCorrespondence: Koji NittaDepartment of Ophthalmology, Fukui-ken Saiseikai Hospital, 7-1 Funabashi, Wadanaka-cho, Fukui 918-8503, JapanTel +81 776 23 1111Fax +81 776 28 8515Email nitta.koji7001@fukui.saiseikai.or.jpBackground: This retrospective study evaluated the effect of adjunctive administration of brimonidine 0.1% on disc hemorrhage (DH) in patients with primary open-angle glaucoma or normal-tension glaucoma who were already treated with other anti-glaucoma drugs.Methods: Patients with DH, before adjunctive therapy with brimonidine, were enrolled. Subjects were excluded if their treatment regimen was changed within 1 year after initiation of adjunctive therapy with brimonidine. We investigated the frequency of DH and intraocular pressure (IOP). Both parameters were compared before and after adjunctive administration of brimonidine.Results: The frequency of DH before and after brimonidine administration was 0.67± 0.68 and 0.31± 0.72 times/year, respectively, with a significant decrease (P=0.01), and the mean IOP before and after brimonidine administration was 12.5± 1.9 and 11.2± 2.2 mmHg, respectively, (P=0.0006) with a significant reduction after adjunctive administration.Conclusion: The results of this study supported the hypothesis that the frequency of DH is reduced by brimonidine alongside lowering of IOP.Keywords: disc hemorrhage, intraocular pressure, brimonidine, primary open-angle glaucoma, normal-tension glaucomaNitta KShimamoto SWajima RTachibana GYamada YDomoto MTakeda RTakahashi YSugiyama KDove Medical Pressarticledisc hemorrhageintraocular pressurebrimonidineprimary open-angle glaucomanormal-tension glaucomaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 213-219 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
disc hemorrhage intraocular pressure brimonidine primary open-angle glaucoma normal-tension glaucoma Ophthalmology RE1-994 |
| spellingShingle |
disc hemorrhage intraocular pressure brimonidine primary open-angle glaucoma normal-tension glaucoma Ophthalmology RE1-994 Nitta K Shimamoto S Wajima R Tachibana G Yamada Y Domoto M Takeda R Takahashi Y Sugiyama K The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients |
| description |
Koji Nitta,1,2 Shiro Shimamoto,3 Ryotaro Wajima,2 Gaku Tachibana,2 Yutaro Yamada,1,2 Miyuki Domoto,1 Ryuji Takeda,4,5 Yoshinari Takahashi,6 Kazuhisa Sugiyama2 1Fukui-ken Saiseikai Hospital, Fukui, Japan; 2Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan; 3Shimamoto Ophthalmology Clinic, Fukui, Japan; 4Department of Nutritional Sciences for Well-Being, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Osaka, Japan; 5Department of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, Nara, Japan; 6Inary Co., Ltd., Tokyo, JapanCorrespondence: Koji NittaDepartment of Ophthalmology, Fukui-ken Saiseikai Hospital, 7-1 Funabashi, Wadanaka-cho, Fukui 918-8503, JapanTel +81 776 23 1111Fax +81 776 28 8515Email nitta.koji7001@fukui.saiseikai.or.jpBackground: This retrospective study evaluated the effect of adjunctive administration of brimonidine 0.1% on disc hemorrhage (DH) in patients with primary open-angle glaucoma or normal-tension glaucoma who were already treated with other anti-glaucoma drugs.Methods: Patients with DH, before adjunctive therapy with brimonidine, were enrolled. Subjects were excluded if their treatment regimen was changed within 1 year after initiation of adjunctive therapy with brimonidine. We investigated the frequency of DH and intraocular pressure (IOP). Both parameters were compared before and after adjunctive administration of brimonidine.Results: The frequency of DH before and after brimonidine administration was 0.67± 0.68 and 0.31± 0.72 times/year, respectively, with a significant decrease (P=0.01), and the mean IOP before and after brimonidine administration was 12.5± 1.9 and 11.2± 2.2 mmHg, respectively, (P=0.0006) with a significant reduction after adjunctive administration.Conclusion: The results of this study supported the hypothesis that the frequency of DH is reduced by brimonidine alongside lowering of IOP.Keywords: disc hemorrhage, intraocular pressure, brimonidine, primary open-angle glaucoma, normal-tension glaucoma |
| format |
article |
| author |
Nitta K Shimamoto S Wajima R Tachibana G Yamada Y Domoto M Takeda R Takahashi Y Sugiyama K |
| author_facet |
Nitta K Shimamoto S Wajima R Tachibana G Yamada Y Domoto M Takeda R Takahashi Y Sugiyama K |
| author_sort |
Nitta K |
| title |
The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients |
| title_short |
The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients |
| title_full |
The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients |
| title_fullStr |
The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients |
| title_full_unstemmed |
The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients |
| title_sort |
effect of brimonidine 0.1% on disc hemorrhage in primary open-angle glaucoma patients |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/b6e64d27c80c49069c79dfd23dff7216 |
| work_keys_str_mv |
AT nittak theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT shimamotos theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT wajimar theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT tachibanag theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT yamaday theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT domotom theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT takedar theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT takahashiy theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT sugiyamak theeffectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT nittak effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT shimamotos effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT wajimar effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT tachibanag effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT yamaday effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT domotom effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT takedar effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT takahashiy effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients AT sugiyamak effectofbrimonidine01ondischemorrhageinprimaryopenangleglaucomapatients |
| _version_ |
1718398432415055872 |