Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats

Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investi...

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Autores principales:	Xiang Wang, Pei Ye, Li Fang, Sheng Ge, Fan Huang, Peter J. Polverini, Weiwei Heng, Lichun Zheng, Qingang Hu, Fuhua Yan, Wenmei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	smoking microbiota digestive tract gastrointestinal tract oral cavity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b6e731baef0c47a78b5b6694b4df3fec
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spelling	oai:doaj.org-article:b6e731baef0c47a78b5b6694b4df3fec2021-12-01T13:55:37ZActive Smoking Induces Aberrations in Digestive Tract Microbiota of Rats2235-298810.3389/fcimb.2021.737204https://doaj.org/article/b6e731baef0c47a78b5b6694b4df3fec2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.737204/fullhttps://doaj.org/toc/2235-2988Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active smoking and characterized the effects of active smoking on the microbiota within multiple regions along the digestive tract. Blood glucose and some metabolic factors levels, the microbial diversity and composition, relative abundances of taxa, bacterial network correlations and predictive functional profiles were compared between the control group and active smoking group. We found that active smoking induced hyperglycemia and significant reductions in serum insulin and leptin levels. Active smoking induced region-specific shifts in microbiota structure, composition, network correlation and metabolism function along the digestive tract. Our results demonstrated that active smoking resulted in a reduced abundance of some potentially beneficial genera (i.e. Clostridium, Turicibacter) and increased abundance of potentially harmful genera (i.e. Desulfovibrio, Bilophila). Functional prediction suggested that amino acid, lipid, propanoate metabolism function could be impaired and antioxidant activity may be triggered. Active smoking may be an overlooked risk to health through its potential effects on the digestive tract microbiota, which is involved in the cause and severity of an array of chronic diseases.Xiang WangXiang WangPei YeLi FangSheng GeFan HuangPeter J. PolveriniWeiwei HengLichun ZhengQingang HuFuhua YanWenmei WangFrontiers Media S.A.articlesmokingmicrobiotadigestive tractgastrointestinal tractoral cavityMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	smoking microbiota digestive tract gastrointestinal tract oral cavity Microbiology QR1-502
spellingShingle	smoking microbiota digestive tract gastrointestinal tract oral cavity Microbiology QR1-502 Xiang Wang Xiang Wang Pei Ye Li Fang Sheng Ge Fan Huang Peter J. Polverini Weiwei Heng Lichun Zheng Qingang Hu Fuhua Yan Wenmei Wang Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats
description	Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active smoking and characterized the effects of active smoking on the microbiota within multiple regions along the digestive tract. Blood glucose and some metabolic factors levels, the microbial diversity and composition, relative abundances of taxa, bacterial network correlations and predictive functional profiles were compared between the control group and active smoking group. We found that active smoking induced hyperglycemia and significant reductions in serum insulin and leptin levels. Active smoking induced region-specific shifts in microbiota structure, composition, network correlation and metabolism function along the digestive tract. Our results demonstrated that active smoking resulted in a reduced abundance of some potentially beneficial genera (i.e. Clostridium, Turicibacter) and increased abundance of potentially harmful genera (i.e. Desulfovibrio, Bilophila). Functional prediction suggested that amino acid, lipid, propanoate metabolism function could be impaired and antioxidant activity may be triggered. Active smoking may be an overlooked risk to health through its potential effects on the digestive tract microbiota, which is involved in the cause and severity of an array of chronic diseases.
format	article
author	Xiang Wang Xiang Wang Pei Ye Li Fang Sheng Ge Fan Huang Peter J. Polverini Weiwei Heng Lichun Zheng Qingang Hu Fuhua Yan Wenmei Wang
author_facet	Xiang Wang Xiang Wang Pei Ye Li Fang Sheng Ge Fan Huang Peter J. Polverini Weiwei Heng Lichun Zheng Qingang Hu Fuhua Yan Wenmei Wang
author_sort	Xiang Wang
title	Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats
title_short	Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats
title_full	Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats
title_fullStr	Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats
title_full_unstemmed	Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats
title_sort	active smoking induces aberrations in digestive tract microbiota of rats
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b6e731baef0c47a78b5b6694b4df3fec
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Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats

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