Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study
Background and aims: In late December 2019, a cluster of progressive pneumonia-like respiratory syndromes broke out in Wuhan, China. As the number of cases continued to rise, the 2019 coronavirus disease (COVID-19) has been declared a global public health emergency. The causative agent, i.e., SARS-C...
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Shahrekord University of Medical Sciences
2021
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oai:doaj.org-article:b6e9bad5cdd24e60bfcf026738235c862021-11-08T05:40:47ZEvaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study2383-436610.34172/ijer.2021.24https://doaj.org/article/b6e9bad5cdd24e60bfcf026738235c862021-08-01T00:00:00Zhttp://ijer.skums.ac.ir/article_246781_d7e3d47a1ef73405c66f82f63bbcd4ed.pdfhttps://doaj.org/toc/2383-4366Background and aims: In late December 2019, a cluster of progressive pneumonia-like respiratory syndromes broke out in Wuhan, China. As the number of cases continued to rise, the 2019 coronavirus disease (COVID-19) has been declared a global public health emergency. The causative agent, i.e., SARS-CoV-2, is a highly contagious strain, which has resulted in the rapid worldwide outbreak of COVID-19. COVID-19 is an overwhelmingly transmissible disease that requires early and accurate diagnosis for proper and timely treatment of suspected cases. Materials and Methods: In order to access the scientific documentation and evidence related to the subject published during 2019 to 2021, English keywords including “COVID-19”, “SARS-CoV-2”, “Diagnosis”, “Immunoglobulin G (IgG)”, “Immunoglobulin M (IgM)”, and ‘Polymerase Chain Reaction (PCR)” were searched in Medline, PubMed, and Google Scholar databases and Persian versions of these keywords were also looked for in Jihad-e Daneshgahi’s Scientific Information Database (SID) and Iranian Journals database (Magiran) Results: With respect to diagnosis, serum antibody assays, nucleic acid sequencing, and radiologic evaluation are among the most reliable methods to rule out the disease in suspicious cases. This review is a synopsis of the pathogenesis of coronavirus, which will mainly focus on the diagnostic methods, as well as laboratory changes in immunoglobulins, polymerase chain reaction results, and computed tomography (CT) findings. Conclusion: Early diagnosis matters in that it not only contributes to the prevention of further transmission of the virus by asymptomatic carriers but also paves the way for clinicians to accurately choose the best therapeutic approach depending on the status of the patients.Roghayeh SheervalilouJamal AhmadzadehSahel AlaviKazhal MobarakiSaman SargaziMilad ShirvalilooAli GolchinAli YekanlouSahar MehranfarShahrekord University of Medical Sciencesarticlecovid-19sars-cov-2diagnosisimmunoglobulin g (igg)immunoglobulin m (igm)polymerase chain reaction (pcr)Therapeutics. PharmacologyRM1-950Infectious and parasitic diseasesRC109-216ENInternational Journal of Epidemiologic Research, Vol 8, Iss 3, Pp 129-137 (2021) |
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covid-19 sars-cov-2 diagnosis immunoglobulin g (igg) immunoglobulin m (igm) polymerase chain reaction (pcr) Therapeutics. Pharmacology RM1-950 Infectious and parasitic diseases RC109-216 |
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covid-19 sars-cov-2 diagnosis immunoglobulin g (igg) immunoglobulin m (igm) polymerase chain reaction (pcr) Therapeutics. Pharmacology RM1-950 Infectious and parasitic diseases RC109-216 Roghayeh Sheervalilou Jamal Ahmadzadeh Sahel Alavi Kazhal Mobaraki Saman Sargazi Milad Shirvaliloo Ali Golchin Ali Yekanlou Sahar Mehranfar Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study |
description |
Background and aims: In late December 2019, a cluster of progressive pneumonia-like respiratory syndromes broke out in Wuhan, China. As the number of cases continued to rise, the 2019 coronavirus disease (COVID-19) has been declared a global public health emergency. The causative agent, i.e., SARS-CoV-2, is a highly contagious strain, which has resulted in the rapid worldwide outbreak of COVID-19. COVID-19 is an overwhelmingly transmissible disease that requires early and accurate diagnosis for proper and timely treatment of suspected cases. Materials and Methods: In order to access the scientific documentation and evidence related to the subject published during 2019 to 2021, English keywords including “COVID-19”, “SARS-CoV-2”, “Diagnosis”, “Immunoglobulin G (IgG)”, “Immunoglobulin M (IgM)”, and ‘Polymerase Chain Reaction (PCR)” were searched in Medline, PubMed, and Google Scholar databases and Persian versions of these keywords were also looked for in Jihad-e Daneshgahi’s Scientific Information Database (SID) and Iranian Journals database (Magiran) Results: With respect to diagnosis, serum antibody assays, nucleic acid sequencing, and radiologic evaluation are among the most reliable methods to rule out the disease in suspicious cases. This review is a synopsis of the pathogenesis of coronavirus, which will mainly focus on the diagnostic methods, as well as laboratory changes in immunoglobulins, polymerase chain reaction results, and computed tomography (CT) findings. Conclusion: Early diagnosis matters in that it not only contributes to the prevention of further transmission of the virus by asymptomatic carriers but also paves the way for clinicians to accurately choose the best therapeutic approach depending on the status of the patients. |
format |
article |
author |
Roghayeh Sheervalilou Jamal Ahmadzadeh Sahel Alavi Kazhal Mobaraki Saman Sargazi Milad Shirvaliloo Ali Golchin Ali Yekanlou Sahar Mehranfar |
author_facet |
Roghayeh Sheervalilou Jamal Ahmadzadeh Sahel Alavi Kazhal Mobaraki Saman Sargazi Milad Shirvaliloo Ali Golchin Ali Yekanlou Sahar Mehranfar |
author_sort |
Roghayeh Sheervalilou |
title |
Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study |
title_short |
Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study |
title_full |
Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study |
title_fullStr |
Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study |
title_full_unstemmed |
Evaluation of Diagnostic Modalities for SARS-Cov-2: A Review Study |
title_sort |
evaluation of diagnostic modalities for sars-cov-2: a review study |
publisher |
Shahrekord University of Medical Sciences |
publishDate |
2021 |
url |
https://doaj.org/article/b6e9bad5cdd24e60bfcf026738235c86 |
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