Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger.

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Autores principales:	Raffaella Rossin, Ron M. Versteegen, Jeremy Wu, Alisher Khasanov, Hans J. Wessels, Erik J. Steenbergen, Wolter ten Hoeve, Henk M. Janssen, Arthur H. A. M. van Onzen, Peter J. Hudson, Marc S. Robillard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6e9e26c80024b1e84795b448f5f9b65
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spelling	oai:doaj.org-article:b6e9e26c80024b1e84795b448f5f9b652021-12-02T15:34:24ZChemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice10.1038/s41467-018-03880-y2041-1723https://doaj.org/article/b6e9e26c80024b1e84795b448f5f9b652018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03880-yhttps://doaj.org/toc/2041-1723Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger.Raffaella RossinRon M. VersteegenJeremy WuAlisher KhasanovHans J. WesselsErik J. SteenbergenWolter ten HoeveHenk M. JanssenArthur H. A. M. van OnzenPeter J. HudsonMarc S. RobillardNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raffaella Rossin Ron M. Versteegen Jeremy Wu Alisher Khasanov Hans J. Wessels Erik J. Steenbergen Wolter ten Hoeve Henk M. Janssen Arthur H. A. M. van Onzen Peter J. Hudson Marc S. Robillard Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
description	Current antibody-drug conjugates (ADCs) target internalising receptors on cancer cells. Here, the authors report the development and in vivo validation of a non-internalising ADC with the capacity to target cancer cells and release its therapeutic cargo extracellularly via a chemical trigger.
format	article
author	Raffaella Rossin Ron M. Versteegen Jeremy Wu Alisher Khasanov Hans J. Wessels Erik J. Steenbergen Wolter ten Hoeve Henk M. Janssen Arthur H. A. M. van Onzen Peter J. Hudson Marc S. Robillard
author_facet	Raffaella Rossin Ron M. Versteegen Jeremy Wu Alisher Khasanov Hans J. Wessels Erik J. Steenbergen Wolter ten Hoeve Henk M. Janssen Arthur H. A. M. van Onzen Peter J. Hudson Marc S. Robillard
author_sort	Raffaella Rossin
title	Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
title_short	Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
title_full	Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
title_fullStr	Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
title_full_unstemmed	Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
title_sort	chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b6e9e26c80024b1e84795b448f5f9b65
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Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

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