Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures

The Suzuki-Miyaura cross coupling is widely used in industrial and academic settings for the formation of carbon-carbon bonds. Here, the authors report a procedure whereby a molecule with multiple reactive carbon-boron bonds can undergo sequential, selective Suzuki-Miyaura reactions without the need...

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Autores principales: Cathleen M. Crudden, Christopher Ziebenhaus, Jason P. G. Rygus, Kazem Ghozati, Phillip J. Unsworth, Masakazu Nambo, Samantha Voth, Marieke Hutchinson, Veronique S. Laberge, Yuuki Maekawa, Daisuke Imao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/b6e9f665794b4f5382ac5381ac70e9eb
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Sumario:The Suzuki-Miyaura cross coupling is widely used in industrial and academic settings for the formation of carbon-carbon bonds. Here, the authors report a procedure whereby a molecule with multiple reactive carbon-boron bonds can undergo sequential, selective Suzuki-Miyaura reactions without the need for protecting groups.