Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects between gene expression and complex traits.

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Autores principales:	Eleonora Porcu, Marie C. Sadler, Kaido Lepik, Chiara Auwerx, Andrew R. Wood, Antoine Weihs, Maroun S. Bou Sleiman, Diogo M. Ribeiro, Stefania Bandinelli, Toshiko Tanaka, Matthias Nauck, Uwe Völker, Olivier Delaneau, Andres Metspalu, Alexander Teumer, Timothy Frayling, Federico A. Santoni, Alexandre Reymond, Zoltán Kutalik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6ea07fec9aa4a9aa84d8abbe352d3b1
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spelling	oai:doaj.org-article:b6ea07fec9aa4a9aa84d8abbe352d3b12021-12-02T18:14:31ZDifferentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome10.1038/s41467-021-25805-y2041-1723https://doaj.org/article/b6ea07fec9aa4a9aa84d8abbe352d3b12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25805-yhttps://doaj.org/toc/2041-1723Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects between gene expression and complex traits.Eleonora PorcuMarie C. SadlerKaido LepikChiara AuwerxAndrew R. WoodAntoine WeihsMaroun S. Bou SleimanDiogo M. RibeiroStefania BandinelliToshiko TanakaMatthias NauckUwe VölkerOlivier DelaneauAndres MetspaluAlexander TeumerTimothy FraylingFederico A. SantoniAlexandre ReymondZoltán KutalikNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eleonora Porcu Marie C. Sadler Kaido Lepik Chiara Auwerx Andrew R. Wood Antoine Weihs Maroun S. Bou Sleiman Diogo M. Ribeiro Stefania Bandinelli Toshiko Tanaka Matthias Nauck Uwe Völker Olivier Delaneau Andres Metspalu Alexander Teumer Timothy Frayling Federico A. Santoni Alexandre Reymond Zoltán Kutalik Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
description	Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects between gene expression and complex traits.
format	article
author	Eleonora Porcu Marie C. Sadler Kaido Lepik Chiara Auwerx Andrew R. Wood Antoine Weihs Maroun S. Bou Sleiman Diogo M. Ribeiro Stefania Bandinelli Toshiko Tanaka Matthias Nauck Uwe Völker Olivier Delaneau Andres Metspalu Alexander Teumer Timothy Frayling Federico A. Santoni Alexandre Reymond Zoltán Kutalik
author_facet	Eleonora Porcu Marie C. Sadler Kaido Lepik Chiara Auwerx Andrew R. Wood Antoine Weihs Maroun S. Bou Sleiman Diogo M. Ribeiro Stefania Bandinelli Toshiko Tanaka Matthias Nauck Uwe Völker Olivier Delaneau Andres Metspalu Alexander Teumer Timothy Frayling Federico A. Santoni Alexandre Reymond Zoltán Kutalik
author_sort	Eleonora Porcu
title	Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
title_short	Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
title_full	Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
title_fullStr	Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
title_full_unstemmed	Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
title_sort	differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6ea07fec9aa4a9aa84d8abbe352d3b1
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Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

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