Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

Glioblastoma is thought to arise from neural stem cells. Here, to investigate this, the authors use single-cell RNA-sequencing to compare glioblastoma to the fetal human brain, and find a similarity between glial progenitor cells and a subpopulation of glioblastoma cells.

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Autores principales:	Charles P. Couturier, Shamini Ayyadhury, Phuong U. Le, Javad Nadaf, Jean Monlong, Gabriele Riva, Redouane Allache, Salma Baig, Xiaohua Yan, Mathieu Bourgey, Changseok Lee, Yu Chang David Wang, V. Wee Yong, Marie-Christine Guiot, Hamed Najafabadi, Bratislav Misic, Jack Antel, Guillaume Bourque, Jiannis Ragoussis, Kevin Petrecca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6efd45faa5f47efaab210dc9f398a89
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spelling	oai:doaj.org-article:b6efd45faa5f47efaab210dc9f398a892021-12-02T18:34:21ZSingle-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy10.1038/s41467-020-17186-52041-1723https://doaj.org/article/b6efd45faa5f47efaab210dc9f398a892020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17186-5https://doaj.org/toc/2041-1723Glioblastoma is thought to arise from neural stem cells. Here, to investigate this, the authors use single-cell RNA-sequencing to compare glioblastoma to the fetal human brain, and find a similarity between glial progenitor cells and a subpopulation of glioblastoma cells.Charles P. CouturierShamini AyyadhuryPhuong U. LeJavad NadafJean MonlongGabriele RivaRedouane AllacheSalma BaigXiaohua YanMathieu BourgeyChangseok LeeYu Chang David WangV. Wee YongMarie-Christine GuiotHamed NajafabadiBratislav MisicJack AntelGuillaume BourqueJiannis RagoussisKevin PetreccaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charles P. Couturier Shamini Ayyadhury Phuong U. Le Javad Nadaf Jean Monlong Gabriele Riva Redouane Allache Salma Baig Xiaohua Yan Mathieu Bourgey Changseok Lee Yu Chang David Wang V. Wee Yong Marie-Christine Guiot Hamed Najafabadi Bratislav Misic Jack Antel Guillaume Bourque Jiannis Ragoussis Kevin Petrecca Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
description	Glioblastoma is thought to arise from neural stem cells. Here, to investigate this, the authors use single-cell RNA-sequencing to compare glioblastoma to the fetal human brain, and find a similarity between glial progenitor cells and a subpopulation of glioblastoma cells.
format	article
author	Charles P. Couturier Shamini Ayyadhury Phuong U. Le Javad Nadaf Jean Monlong Gabriele Riva Redouane Allache Salma Baig Xiaohua Yan Mathieu Bourgey Changseok Lee Yu Chang David Wang V. Wee Yong Marie-Christine Guiot Hamed Najafabadi Bratislav Misic Jack Antel Guillaume Bourque Jiannis Ragoussis Kevin Petrecca
author_facet	Charles P. Couturier Shamini Ayyadhury Phuong U. Le Javad Nadaf Jean Monlong Gabriele Riva Redouane Allache Salma Baig Xiaohua Yan Mathieu Bourgey Changseok Lee Yu Chang David Wang V. Wee Yong Marie-Christine Guiot Hamed Najafabadi Bratislav Misic Jack Antel Guillaume Bourque Jiannis Ragoussis Kevin Petrecca
author_sort	Charles P. Couturier
title	Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
title_short	Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
title_full	Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
title_fullStr	Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
title_full_unstemmed	Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
title_sort	single-cell rna-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b6efd45faa5f47efaab210dc9f398a89
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Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

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