TMAO: a potential mediator of clopidogrel resistance

Abstract Trimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TM...

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Autores principales:	Ruisong Ma, Wenwen Fu, Jing Zhang, Xiaorong Hu, Jun Yang, Hong Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6f0fcb212214607899980f1b51ec8cd
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spelling	oai:doaj.org-article:b6f0fcb212214607899980f1b51ec8cd2021-12-02T17:04:07ZTMAO: a potential mediator of clopidogrel resistance10.1038/s41598-021-85950-82045-2322https://doaj.org/article/b6f0fcb212214607899980f1b51ec8cd2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85950-8https://doaj.org/toc/2045-2322Abstract Trimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TMAO. The present study aimed investigate the effects of TMAO on clopidogrel in ischemia and reperfusion (IR) model in rats. Clopidogrel could (1) promote the production of platelets, induce an increase in the platelet-larger cell ratio; (2) prolong the tail bleeding time; (3) reduce platelet aggregation function, induced by ADP, and alleviate myocardial thrombus burden. TMAO could partially offset the effects of clopidogrel and induce CR. Thus, the present study demonstrated that circulating TMAO could reduce the inhibitory effects of clopidogrel on platelet aggregation. TMAO may be a potential mediator of clopidogrel resistance.Ruisong MaWenwen FuJing ZhangXiaorong HuJun YangHong JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruisong Ma Wenwen Fu Jing Zhang Xiaorong Hu Jun Yang Hong Jiang TMAO: a potential mediator of clopidogrel resistance
description	Abstract Trimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TMAO. The present study aimed investigate the effects of TMAO on clopidogrel in ischemia and reperfusion (IR) model in rats. Clopidogrel could (1) promote the production of platelets, induce an increase in the platelet-larger cell ratio; (2) prolong the tail bleeding time; (3) reduce platelet aggregation function, induced by ADP, and alleviate myocardial thrombus burden. TMAO could partially offset the effects of clopidogrel and induce CR. Thus, the present study demonstrated that circulating TMAO could reduce the inhibitory effects of clopidogrel on platelet aggregation. TMAO may be a potential mediator of clopidogrel resistance.
format	article
author	Ruisong Ma Wenwen Fu Jing Zhang Xiaorong Hu Jun Yang Hong Jiang
author_facet	Ruisong Ma Wenwen Fu Jing Zhang Xiaorong Hu Jun Yang Hong Jiang
author_sort	Ruisong Ma
title	TMAO: a potential mediator of clopidogrel resistance
title_short	TMAO: a potential mediator of clopidogrel resistance
title_full	TMAO: a potential mediator of clopidogrel resistance
title_fullStr	TMAO: a potential mediator of clopidogrel resistance
title_full_unstemmed	TMAO: a potential mediator of clopidogrel resistance
title_sort	tmao: a potential mediator of clopidogrel resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6f0fcb212214607899980f1b51ec8cd
work_keys_str_mv	AT ruisongma tmaoapotentialmediatorofclopidogrelresistance AT wenwenfu tmaoapotentialmediatorofclopidogrelresistance AT jingzhang tmaoapotentialmediatorofclopidogrelresistance AT xiaoronghu tmaoapotentialmediatorofclopidogrelresistance AT junyang tmaoapotentialmediatorofclopidogrelresistance AT hongjiang tmaoapotentialmediatorofclopidogrelresistance
_version_	1718381870587052032

TMAO: a potential mediator of clopidogrel resistance

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