Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

ABSTRACT Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line tre...

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Autores principales:	Nicolas Papon, Florent Morio, Dominique Sanglard
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Aspergillus fumigatus caspofungin tolerance paradoxical growth transcription factors Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b6f21d2831244aad895e39a2ebededf9
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spelling	oai:doaj.org-article:b6f21d2831244aad895e39a2ebededf92021-11-15T15:56:45ZSignaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>10.1128/mBio.01816-202150-7511https://doaj.org/article/b6f21d2831244aad895e39a2ebededf92020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01816-20https://doaj.org/toc/2150-7511ABSTRACT Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line treatment and prophylaxis of invasive aspergillosis. In this context, some of the latest antifungals, i.e., echinocandins, have gained attention. Even though acquired resistance to echinocandins is yet uncommon in A. fumigatus clinical isolates, some strains exhibit another characteristic that relies on their capacity to grow at suprainhibitory echinocandin concentrations in vitro. This intriguing phenomenon, especially observed with caspofungin and now referred to as the caspofungin paradoxical effect (CPE), relies on molecular mechanisms that were hitherto little understood. Here, we discuss the recent key findings of Valero and colleagues published in mBio (C. Valero, A. C. Colabardini, J. Chiaratto, L. Pardeshi, et al., mBio 11:e00816-20, 2020, https://doi.org/10.1128/mBio.00816-20) that will allow a better understanding of the complex regulatory pathway involved in governing the response of A. fumigatus to caspofungin.Nicolas PaponFlorent MorioDominique SanglardAmerican Society for MicrobiologyarticleAspergillus fumigatuscaspofungintoleranceparadoxical growthtranscription factorsMicrobiologyQR1-502ENmBio, Vol 11, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aspergillus fumigatus caspofungin tolerance paradoxical growth transcription factors Microbiology QR1-502
spellingShingle	Aspergillus fumigatus caspofungin tolerance paradoxical growth transcription factors Microbiology QR1-502 Nicolas Papon Florent Morio Dominique Sanglard Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
description	ABSTRACT Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line treatment and prophylaxis of invasive aspergillosis. In this context, some of the latest antifungals, i.e., echinocandins, have gained attention. Even though acquired resistance to echinocandins is yet uncommon in A. fumigatus clinical isolates, some strains exhibit another characteristic that relies on their capacity to grow at suprainhibitory echinocandin concentrations in vitro. This intriguing phenomenon, especially observed with caspofungin and now referred to as the caspofungin paradoxical effect (CPE), relies on molecular mechanisms that were hitherto little understood. Here, we discuss the recent key findings of Valero and colleagues published in mBio (C. Valero, A. C. Colabardini, J. Chiaratto, L. Pardeshi, et al., mBio 11:e00816-20, 2020, https://doi.org/10.1128/mBio.00816-20) that will allow a better understanding of the complex regulatory pathway involved in governing the response of A. fumigatus to caspofungin.
format	article
author	Nicolas Papon Florent Morio Dominique Sanglard
author_facet	Nicolas Papon Florent Morio Dominique Sanglard
author_sort	Nicolas Papon
title	Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_short	Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_full	Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_fullStr	Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_full_unstemmed	Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>
title_sort	signaling pathways governing the caspofungin paradoxical effect in <named-content content-type="genus-species">aspergillus fumigatus</named-content>
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/b6f21d2831244aad895e39a2ebededf9
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Signaling Pathways Governing the Caspofungin Paradoxical Effect in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

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