Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis

Abstract Fluid resuscitation via colon (FRVC) is a complementary therapeutic procedure for early-stage cases of severe acute pancreatitis (SAP). The expression of intestinal dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) regulates systemic inflammation. This...

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Autores principales:	Tongtian Ni, Lili Xu, Silei Sun, Li Ma, Bing Zhao, Weijun Zhou, Yi Wen, Ning Ning, Erzhen Chen, Ying Chen, Enqiang Mao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6f255aa45534daf8d6fc582bb3f6cfd
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spelling	oai:doaj.org-article:b6f255aa45534daf8d6fc582bb3f6cfd2021-12-02T17:08:44ZFluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis10.1038/s41598-021-96394-52045-2322https://doaj.org/article/b6f255aa45534daf8d6fc582bb3f6cfd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96394-5https://doaj.org/toc/2045-2322Abstract Fluid resuscitation via colon (FRVC) is a complementary therapeutic procedure for early-stage cases of severe acute pancreatitis (SAP). The expression of intestinal dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) regulates systemic inflammation. This study aimed to investigate the effect of FRVC on the expression of DC-SIGN in the colon tissue of SAP rats and its effect on the early response of systemic inflammatory and multiple organ injury. SAP was induced in rats via retrograde injection of sodium taurocholate into the biliopancreatic duct. DC-SIGN expression of appeared in the proximal and distal colon. Histological characteristics and inflammatory cytokines were examined to compare the effect of FRVC and intravenous fluid resuscitation (IVFR). The results showed that DC-SIGN expression in the proximal colon increased in a time-dependent manner in the early-stage of SAP rats. FRVC inhibited DC-SIGN expression in the proximal colon. Both FRVC and IVFR alleviated histological injuries of the pancreas and colon. However, FRVC had an advantage over IVFR in alleviating lung injury and reducing serum TNF-α, IL-6 and LPS. These results suggest that FRVC treatment might help suppress systemic inflammation and prevent subsequent organ failure in early-stage SAP rats likely through inhibiting DC-SIGN expression in the proximal colon.Tongtian NiLili XuSilei SunLi MaBing ZhaoWeijun ZhouYi WenNing NingErzhen ChenYing ChenEnqiang MaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tongtian Ni Lili Xu Silei Sun Li Ma Bing Zhao Weijun Zhou Yi Wen Ning Ning Erzhen Chen Ying Chen Enqiang Mao Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis
description	Abstract Fluid resuscitation via colon (FRVC) is a complementary therapeutic procedure for early-stage cases of severe acute pancreatitis (SAP). The expression of intestinal dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) regulates systemic inflammation. This study aimed to investigate the effect of FRVC on the expression of DC-SIGN in the colon tissue of SAP rats and its effect on the early response of systemic inflammatory and multiple organ injury. SAP was induced in rats via retrograde injection of sodium taurocholate into the biliopancreatic duct. DC-SIGN expression of appeared in the proximal and distal colon. Histological characteristics and inflammatory cytokines were examined to compare the effect of FRVC and intravenous fluid resuscitation (IVFR). The results showed that DC-SIGN expression in the proximal colon increased in a time-dependent manner in the early-stage of SAP rats. FRVC inhibited DC-SIGN expression in the proximal colon. Both FRVC and IVFR alleviated histological injuries of the pancreas and colon. However, FRVC had an advantage over IVFR in alleviating lung injury and reducing serum TNF-α, IL-6 and LPS. These results suggest that FRVC treatment might help suppress systemic inflammation and prevent subsequent organ failure in early-stage SAP rats likely through inhibiting DC-SIGN expression in the proximal colon.
format	article
author	Tongtian Ni Lili Xu Silei Sun Li Ma Bing Zhao Weijun Zhou Yi Wen Ning Ning Erzhen Chen Ying Chen Enqiang Mao
author_facet	Tongtian Ni Lili Xu Silei Sun Li Ma Bing Zhao Weijun Zhou Yi Wen Ning Ning Erzhen Chen Ying Chen Enqiang Mao
author_sort	Tongtian Ni
title	Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis
title_short	Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis
title_full	Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis
title_fullStr	Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis
title_full_unstemmed	Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis
title_sort	fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6f255aa45534daf8d6fc582bb3f6cfd
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Fluid resuscitation via colon alleviates systemic inflammation in rats with early-stage severe acute pancreatitis

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