Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application

Yongwei Hao,1,* Lei Wang,1,2,* Bingxiang Zhang,1 Dong Li,1 Dehui Meng,1 Jinjin Shi,1 Hongling Zhang,1 Zhenzhong Zhang,1 Yun Zhang11School of Pharmaceutical Sciences, 2School of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, People’s Republic of China *These...

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Autores principales:	Hao Y, Wang L, Zhang B, Li D, Meng D, Shi J, Zhang H, Zhang Z, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	manganese dioxide nanosheets hyaluronic acid magnetic contrast imaging theranostic application Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b6f3b62af6454b41ab89c546571dcd78
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spelling	oai:doaj.org-article:b6f3b62af6454b41ab89c546571dcd782021-12-02T02:31:34ZManganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application1178-2013https://doaj.org/article/b6f3b62af6454b41ab89c546571dcd782016-04-01T00:00:00Zhttps://www.dovepress.com/manganese-dioxide-nanosheets-based-redoxph-responsive-drug-delivery-sy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yongwei Hao,1,* Lei Wang,1,2,* Bingxiang Zhang,1 Dong Li,1 Dehui Meng,1 Jinjin Shi,1 Hongling Zhang,1 Zhenzhong Zhang,1 Yun Zhang11School of Pharmaceutical Sciences, 2School of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The aim of this study was to construct redox- and pH-responsive degradable manganese dioxide (MnO2) nanosheets for cancer theranostic application. The small MnO2 nanosheets were synthesized, and then functionalized by hyaluronic acid (HA), demonstrating excellent stability and tumor-targeting ability. Cisplatin (cis-diamminedichloroplatinum [CDDP]) was absorbed by the nanosheets through a physical action, which was designed as MnO2/HA/CDDP. The prepared MnO2/HA/CDDP formulation was able to efficiently deliver CDDP to tumor cells in vitro and in vivo, resulting in improved therapeutic efficiency. Subsequently, they were triggered by lower pH and higher level of reduced glutathione to generate Mn2+, enabling magnetic resonance imaging. The smart multifunctional system combining efficient magnetic resonance imaging and chemotherapy has the potential to be used as a tumor-targeting theranostic nanomedicine.Keywords: manganese dioxide nanosheets, hyaluronic acid, magnetic resonance imaging, theranostic applicationHao YWang LZhang BLi DMeng DShi JZhang HZhang ZZhang YDove Medical Pressarticlemanganese dioxide nanosheetshyaluronic acidmagnetic contrast imagingtheranostic applicationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1759-1778 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	manganese dioxide nanosheets hyaluronic acid magnetic contrast imaging theranostic application Medicine (General) R5-920
spellingShingle	manganese dioxide nanosheets hyaluronic acid magnetic contrast imaging theranostic application Medicine (General) R5-920 Hao Y Wang L Zhang B Li D Meng D Shi J Zhang H Zhang Z Zhang Y Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application
description	Yongwei Hao,1,* Lei Wang,1,2,* Bingxiang Zhang,1 Dong Li,1 Dehui Meng,1 Jinjin Shi,1 Hongling Zhang,1 Zhenzhong Zhang,1 Yun Zhang11School of Pharmaceutical Sciences, 2School of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, People’s Republic of China *These authors contributed equally to this work Abstract: The aim of this study was to construct redox- and pH-responsive degradable manganese dioxide (MnO2) nanosheets for cancer theranostic application. The small MnO2 nanosheets were synthesized, and then functionalized by hyaluronic acid (HA), demonstrating excellent stability and tumor-targeting ability. Cisplatin (cis-diamminedichloroplatinum [CDDP]) was absorbed by the nanosheets through a physical action, which was designed as MnO2/HA/CDDP. The prepared MnO2/HA/CDDP formulation was able to efficiently deliver CDDP to tumor cells in vitro and in vivo, resulting in improved therapeutic efficiency. Subsequently, they were triggered by lower pH and higher level of reduced glutathione to generate Mn2+, enabling magnetic resonance imaging. The smart multifunctional system combining efficient magnetic resonance imaging and chemotherapy has the potential to be used as a tumor-targeting theranostic nanomedicine.Keywords: manganese dioxide nanosheets, hyaluronic acid, magnetic resonance imaging, theranostic application
format	article
author	Hao Y Wang L Zhang B Li D Meng D Shi J Zhang H Zhang Z Zhang Y
author_facet	Hao Y Wang L Zhang B Li D Meng D Shi J Zhang H Zhang Z Zhang Y
author_sort	Hao Y
title	Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application
title_short	Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application
title_full	Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application
title_fullStr	Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application
title_full_unstemmed	Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application
title_sort	manganese dioxide nanosheets-based redox/ph-responsive drug delivery system for cancer theranostic application
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b6f3b62af6454b41ab89c546571dcd78
work_keys_str_mv	AT haoy manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT wangl manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT zhangb manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT lid manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT mengd manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT shij manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT zhangh manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT zhangz manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication AT zhangy manganesedioxidenanosheetsbasedredoxphresponsivedrugdeliverysystemforcancertheranosticapplication
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Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application

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