Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI

Abstract Knee injury often triggers post-traumatic osteoarthritis (PTOA) that affects articular cartilage (AC), subchondral bone, meniscus and the synovial membrane. The available treatments for PTOA are largely ineffective due to late diagnosis past the “treatment window”. This study aimed to devel...

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Autores principales:	Tonima S. Ali, Indira Prasadam, Yin Xiao, Konstantin I. Momot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b6f6186459f24e999737711e9f7dda41
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spelling	oai:doaj.org-article:b6f6186459f24e999737711e9f7dda412021-12-02T16:08:26ZProgression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI10.1038/s41598-018-25186-12045-2322https://doaj.org/article/b6f6186459f24e999737711e9f7dda412018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25186-1https://doaj.org/toc/2045-2322Abstract Knee injury often triggers post-traumatic osteoarthritis (PTOA) that affects articular cartilage (AC), subchondral bone, meniscus and the synovial membrane. The available treatments for PTOA are largely ineffective due to late diagnosis past the “treatment window”. This study aimed to develop a detailed understanding of the time line of the progression of PTOA in murine models through longitudinal observation of the femorotibial joint from the onset of the disease to the advanced stage. Quantitative magnetic resonance microimaging (µMRI) and histology were used to evaluate PTOA-associated changes in the knee joints of rats subjected to knee meniscectomy. Systematic longitudinal changes in the articular cartilage thickness, cartilage T 2 and the T 2 of epiphysis within medial condyles of the tibia were all found to be associated with the development of PTOA in the animals. The following pathogenesis cascade was found to precede advanced PTOA: meniscal injury → AC swelling → subchondral bone remodelling → proteoglycan depletion → free water influx → cartilage erosion. Importantly, the imaging protocol used was entirely MRI-based. This protocol is potentially suitable for whole-knee longitudinal, non-invasive assessment of the development of OA. The results of this work will inform the improvement of the imaging methods for early diagnosis of PTOA.Tonima S. AliIndira PrasadamYin XiaoKonstantin I. MomotNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tonima S. Ali Indira Prasadam Yin Xiao Konstantin I. Momot Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI
description	Abstract Knee injury often triggers post-traumatic osteoarthritis (PTOA) that affects articular cartilage (AC), subchondral bone, meniscus and the synovial membrane. The available treatments for PTOA are largely ineffective due to late diagnosis past the “treatment window”. This study aimed to develop a detailed understanding of the time line of the progression of PTOA in murine models through longitudinal observation of the femorotibial joint from the onset of the disease to the advanced stage. Quantitative magnetic resonance microimaging (µMRI) and histology were used to evaluate PTOA-associated changes in the knee joints of rats subjected to knee meniscectomy. Systematic longitudinal changes in the articular cartilage thickness, cartilage T 2 and the T 2 of epiphysis within medial condyles of the tibia were all found to be associated with the development of PTOA in the animals. The following pathogenesis cascade was found to precede advanced PTOA: meniscal injury → AC swelling → subchondral bone remodelling → proteoglycan depletion → free water influx → cartilage erosion. Importantly, the imaging protocol used was entirely MRI-based. This protocol is potentially suitable for whole-knee longitudinal, non-invasive assessment of the development of OA. The results of this work will inform the improvement of the imaging methods for early diagnosis of PTOA.
format	article
author	Tonima S. Ali Indira Prasadam Yin Xiao Konstantin I. Momot
author_facet	Tonima S. Ali Indira Prasadam Yin Xiao Konstantin I. Momot
author_sort	Tonima S. Ali
title	Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI
title_short	Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI
title_full	Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI
title_fullStr	Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI
title_full_unstemmed	Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI
title_sort	progression of post-traumatic osteoarthritis in rat meniscectomy models: comprehensive monitoring using mri
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b6f6186459f24e999737711e9f7dda41
work_keys_str_mv	AT tonimasali progressionofposttraumaticosteoarthritisinratmeniscectomymodelscomprehensivemonitoringusingmri AT indiraprasadam progressionofposttraumaticosteoarthritisinratmeniscectomymodelscomprehensivemonitoringusingmri AT yinxiao progressionofposttraumaticosteoarthritisinratmeniscectomymodelscomprehensivemonitoringusingmri AT konstantinimomot progressionofposttraumaticosteoarthritisinratmeniscectomymodelscomprehensivemonitoringusingmri
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Progression of Post-Traumatic Osteoarthritis in rat meniscectomy models: Comprehensive monitoring using MRI

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