Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Neurofilament (NfL) levels in CSF and blood have been established as a biomarker of neuronal damage in neurodegenerative diseases, and there is an age-dependent increase in NfL levels in CSF. Here the authors demonstrate that serum NfL levels increase in healthy aging people and predict and correlat...

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Autores principales:	Michael Khalil, Lukas Pirpamer, Edith Hofer, Margarete M. Voortman, Christian Barro, David Leppert, Pascal Benkert, Stefan Ropele, Christian Enzinger, Franz Fazekas, Reinhold Schmidt, Jens Kuhle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6f6b4d61b9d441eaa7ef614a3d901da
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spelling	oai:doaj.org-article:b6f6b4d61b9d441eaa7ef614a3d901da2021-12-02T17:31:55ZSerum neurofilament light levels in normal aging and their association with morphologic brain changes10.1038/s41467-020-14612-62041-1723https://doaj.org/article/b6f6b4d61b9d441eaa7ef614a3d901da2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14612-6https://doaj.org/toc/2041-1723Neurofilament (NfL) levels in CSF and blood have been established as a biomarker of neuronal damage in neurodegenerative diseases, and there is an age-dependent increase in NfL levels in CSF. Here the authors demonstrate that serum NfL levels increase in healthy aging people and predict and correlate with brain volume loss.Michael KhalilLukas PirpamerEdith HoferMargarete M. VoortmanChristian BarroDavid LeppertPascal BenkertStefan RopeleChristian EnzingerFranz FazekasReinhold SchmidtJens KuhleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Khalil Lukas Pirpamer Edith Hofer Margarete M. Voortman Christian Barro David Leppert Pascal Benkert Stefan Ropele Christian Enzinger Franz Fazekas Reinhold Schmidt Jens Kuhle Serum neurofilament light levels in normal aging and their association with morphologic brain changes
description	Neurofilament (NfL) levels in CSF and blood have been established as a biomarker of neuronal damage in neurodegenerative diseases, and there is an age-dependent increase in NfL levels in CSF. Here the authors demonstrate that serum NfL levels increase in healthy aging people and predict and correlate with brain volume loss.
format	article
author	Michael Khalil Lukas Pirpamer Edith Hofer Margarete M. Voortman Christian Barro David Leppert Pascal Benkert Stefan Ropele Christian Enzinger Franz Fazekas Reinhold Schmidt Jens Kuhle
author_facet	Michael Khalil Lukas Pirpamer Edith Hofer Margarete M. Voortman Christian Barro David Leppert Pascal Benkert Stefan Ropele Christian Enzinger Franz Fazekas Reinhold Schmidt Jens Kuhle
author_sort	Michael Khalil
title	Serum neurofilament light levels in normal aging and their association with morphologic brain changes
title_short	Serum neurofilament light levels in normal aging and their association with morphologic brain changes
title_full	Serum neurofilament light levels in normal aging and their association with morphologic brain changes
title_fullStr	Serum neurofilament light levels in normal aging and their association with morphologic brain changes
title_full_unstemmed	Serum neurofilament light levels in normal aging and their association with morphologic brain changes
title_sort	serum neurofilament light levels in normal aging and their association with morphologic brain changes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b6f6b4d61b9d441eaa7ef614a3d901da
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Serum neurofilament light levels in normal aging and their association with morphologic brain changes

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