The miRNome of Depression

Depression is an effect of complex interactions between genetic, epigenetic and environmental factors. It is well established that stress responses are associated with multiple modest and often dynamic molecular changes in the homeostatic balance, rather than with a single genetic factor that has a...

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Autores principales:	Dariusz Żurawek, Gustavo Turecki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microRNA depression antidepressant treatment human brain biomarker miRNome Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b6fbc2047a52429b8a9c7399fb76d696
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spelling	oai:doaj.org-article:b6fbc2047a52429b8a9c7399fb76d6962021-11-11T16:48:07ZThe miRNome of Depression10.3390/ijms2221113121422-00671661-6596https://doaj.org/article/b6fbc2047a52429b8a9c7399fb76d6962021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11312https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Depression is an effect of complex interactions between genetic, epigenetic and environmental factors. It is well established that stress responses are associated with multiple modest and often dynamic molecular changes in the homeostatic balance, rather than with a single genetic factor that has a strong phenotypic penetration. As depression is a multifaceted phenotype, it is important to study biochemical pathways that can regulate the overall allostasis of the brain. One such biological system that has the potential to fine-tune a multitude of diverse molecular processes is RNA interference (RNAi). RNAi is an epigenetic process showing a very low level of evolutionary diversity, and relies on the posttranscriptional regulation of gene expression using, in the case of mammals, primarily short (17–23 nucleotides) noncoding RNA transcripts called microRNAs (miRNA). In this review, our objective was to examine, summarize and discuss recent advances in the field of biomedical and clinical research on the role of miRNA-mediated regulation of gene expression in the development of depression. We focused on studies investigating post-mortem brain tissue of individuals with depression, as well as research aiming to elucidate the biomarker potential of miRNAs in depression and antidepressant response.Dariusz ŻurawekGustavo TureckiMDPI AGarticlemicroRNAdepressionantidepressant treatmenthuman brainbiomarkermiRNomeBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11312, p 11312 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNA depression antidepressant treatment human brain biomarker miRNome Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	microRNA depression antidepressant treatment human brain biomarker miRNome Biology (General) QH301-705.5 Chemistry QD1-999 Dariusz Żurawek Gustavo Turecki The miRNome of Depression
description	Depression is an effect of complex interactions between genetic, epigenetic and environmental factors. It is well established that stress responses are associated with multiple modest and often dynamic molecular changes in the homeostatic balance, rather than with a single genetic factor that has a strong phenotypic penetration. As depression is a multifaceted phenotype, it is important to study biochemical pathways that can regulate the overall allostasis of the brain. One such biological system that has the potential to fine-tune a multitude of diverse molecular processes is RNA interference (RNAi). RNAi is an epigenetic process showing a very low level of evolutionary diversity, and relies on the posttranscriptional regulation of gene expression using, in the case of mammals, primarily short (17–23 nucleotides) noncoding RNA transcripts called microRNAs (miRNA). In this review, our objective was to examine, summarize and discuss recent advances in the field of biomedical and clinical research on the role of miRNA-mediated regulation of gene expression in the development of depression. We focused on studies investigating post-mortem brain tissue of individuals with depression, as well as research aiming to elucidate the biomarker potential of miRNAs in depression and antidepressant response.
format	article
author	Dariusz Żurawek Gustavo Turecki
author_facet	Dariusz Żurawek Gustavo Turecki
author_sort	Dariusz Żurawek
title	The miRNome of Depression
title_short	The miRNome of Depression
title_full	The miRNome of Depression
title_fullStr	The miRNome of Depression
title_full_unstemmed	The miRNome of Depression
title_sort	mirnome of depression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b6fbc2047a52429b8a9c7399fb76d696
work_keys_str_mv	AT dariuszzurawek themirnomeofdepression AT gustavoturecki themirnomeofdepression AT dariuszzurawek mirnomeofdepression AT gustavoturecki mirnomeofdepression
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The miRNome of Depression

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