Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response

Aleksandar R Zivkovic, Jochen Bender, Thorsten Brenner, Stefan Hofer,* Karsten Schmidt* Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany *These authors contributed equally to this work Purpose: Early diagnosis of systemic inflammatory response syndrome is fu...

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Autores principales:	Zivkovic AR, Bender J, Brenner T, Hofer S, Schmidt K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	trauma injury early diagnostics cholinergic pseudocholinesterase SIRS Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b6fd0ab6fa674644bddd590f4c7a981e
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spelling	oai:doaj.org-article:b6fd0ab6fa674644bddd590f4c7a981e2021-12-02T02:04:19ZReduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response1178-7031https://doaj.org/article/b6fd0ab6fa674644bddd590f4c7a981e2016-11-01T00:00:00Zhttps://www.dovepress.com/reduced--butyrylcholinesterase-activity-is-an-early-indicator-of-traum-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Aleksandar R Zivkovic, Jochen Bender, Thorsten Brenner, Stefan Hofer,* Karsten Schmidt* Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany *These authors contributed equally to this work Purpose: Early diagnosis of systemic inflammatory response syndrome is fundamentally important for an effective and a goal-directed therapy. Various inflammation biomarkers have been used in clinical and experimental practice. However, a definitive diagnostic tool for an early detection of systemic inflammation remains to be identified. Acetylcholine (Ach) has been shown to play an important role in the inflammatory response. Serum cholinesterase (butyrylcholinesterase [BChE]) is the major Ach hydrolyzing enzyme in blood. The role of this enzyme during inflammation has not yet been fully understood. This study tests whether a reduction in the BChE activity could indicate the onset of the systemic inflammatory response upon traumatic injury. Patients and methods: This observational study measured BChE activity in patients with traumatic injury admitted to the emergency room by using point-of-care-test system (POCT). In addition, the levels of routine inflammation biomarkers during the initial treatment period were measured. Injury Severity Score was used to assess the trauma severity. Results: Altered BChE activity was correlated with trauma severity, resulting in systemic inflammation. Reduction in the BChE activity was detected significantly earlier compared to those of routinely measured inflammatory biomarkers. Conclusion: This study suggests that the BChE activity reduction might serve as an early indicator of acute systemic inflammation. Furthermore, BChE activity, measured using a POCT system, might play an important role in the early diagnosis of the trauma-induced systemic inflammation. Keywords: trauma, injury, early diagnostics, cholinergic, pseudocholinesterase, SIRSZivkovic ARBender JBrenner THofer SSchmidt KDove Medical Pressarticletraumainjuryearly diagnosticscholinergicpseudocholinesteraseSIRSPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 9, Pp 221-230 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	trauma injury early diagnostics cholinergic pseudocholinesterase SIRS Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	trauma injury early diagnostics cholinergic pseudocholinesterase SIRS Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Zivkovic AR Bender J Brenner T Hofer S Schmidt K Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
description	Aleksandar R Zivkovic, Jochen Bender, Thorsten Brenner, Stefan Hofer,* Karsten Schmidt* Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany *These authors contributed equally to this work Purpose: Early diagnosis of systemic inflammatory response syndrome is fundamentally important for an effective and a goal-directed therapy. Various inflammation biomarkers have been used in clinical and experimental practice. However, a definitive diagnostic tool for an early detection of systemic inflammation remains to be identified. Acetylcholine (Ach) has been shown to play an important role in the inflammatory response. Serum cholinesterase (butyrylcholinesterase [BChE]) is the major Ach hydrolyzing enzyme in blood. The role of this enzyme during inflammation has not yet been fully understood. This study tests whether a reduction in the BChE activity could indicate the onset of the systemic inflammatory response upon traumatic injury. Patients and methods: This observational study measured BChE activity in patients with traumatic injury admitted to the emergency room by using point-of-care-test system (POCT). In addition, the levels of routine inflammation biomarkers during the initial treatment period were measured. Injury Severity Score was used to assess the trauma severity. Results: Altered BChE activity was correlated with trauma severity, resulting in systemic inflammation. Reduction in the BChE activity was detected significantly earlier compared to those of routinely measured inflammatory biomarkers. Conclusion: This study suggests that the BChE activity reduction might serve as an early indicator of acute systemic inflammation. Furthermore, BChE activity, measured using a POCT system, might play an important role in the early diagnosis of the trauma-induced systemic inflammation. Keywords: trauma, injury, early diagnostics, cholinergic, pseudocholinesterase, SIRS
format	article
author	Zivkovic AR Bender J Brenner T Hofer S Schmidt K
author_facet	Zivkovic AR Bender J Brenner T Hofer S Schmidt K
author_sort	Zivkovic AR
title	Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
title_short	Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
title_full	Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
title_fullStr	Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
title_full_unstemmed	Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
title_sort	reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b6fd0ab6fa674644bddd590f4c7a981e
work_keys_str_mv	AT zivkovicar reducedbutyrylcholinesteraseactivityisanearlyindicatoroftraumainducedacutesystemicinflammatoryresponse AT benderj reducedbutyrylcholinesteraseactivityisanearlyindicatoroftraumainducedacutesystemicinflammatoryresponse AT brennert reducedbutyrylcholinesteraseactivityisanearlyindicatoroftraumainducedacutesystemicinflammatoryresponse AT hofers reducedbutyrylcholinesteraseactivityisanearlyindicatoroftraumainducedacutesystemicinflammatoryresponse AT schmidtk reducedbutyrylcholinesteraseactivityisanearlyindicatoroftraumainducedacutesystemicinflammatoryresponse
_version_	1718402729117745152

Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response

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