16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

16p11.2 CNVs are associated with neurodevelopmental disorders. Here, the authors show that 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.

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Autores principales:	Maria Sundberg, Hannah Pinson, Richard S. Smith, Kellen D. Winden, Pooja Venugopal, Derek J. C. Tai, James F. Gusella, Michael E. Talkowski, Christopher A. Walsh, Max Tegmark, Mustafa Sahin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b6ffb9fd39d845a3b76fce24f582a800
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spelling	oai:doaj.org-article:b6ffb9fd39d845a3b76fce24f582a8002021-12-02T14:58:43Z16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro10.1038/s41467-021-23113-z2041-1723https://doaj.org/article/b6ffb9fd39d845a3b76fce24f582a8002021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23113-zhttps://doaj.org/toc/2041-172316p11.2 CNVs are associated with neurodevelopmental disorders. Here, the authors show that 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.Maria SundbergHannah PinsonRichard S. SmithKellen D. WindenPooja VenugopalDerek J. C. TaiJames F. GusellaMichael E. TalkowskiChristopher A. WalshMax TegmarkMustafa SahinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Sundberg Hannah Pinson Richard S. Smith Kellen D. Winden Pooja Venugopal Derek J. C. Tai James F. Gusella Michael E. Talkowski Christopher A. Walsh Max Tegmark Mustafa Sahin 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
description	16p11.2 CNVs are associated with neurodevelopmental disorders. Here, the authors show that 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.
format	article
author	Maria Sundberg Hannah Pinson Richard S. Smith Kellen D. Winden Pooja Venugopal Derek J. C. Tai James F. Gusella Michael E. Talkowski Christopher A. Walsh Max Tegmark Mustafa Sahin
author_facet	Maria Sundberg Hannah Pinson Richard S. Smith Kellen D. Winden Pooja Venugopal Derek J. C. Tai James F. Gusella Michael E. Talkowski Christopher A. Walsh Max Tegmark Mustafa Sahin
author_sort	Maria Sundberg
title	16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
title_short	16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
title_full	16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
title_fullStr	16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
title_full_unstemmed	16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
title_sort	16p11.2 deletion is associated with hyperactivation of human ipsc-derived dopaminergic neuron networks and is rescued by rhoa inhibition in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b6ffb9fd39d845a3b76fce24f582a800
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16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

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