Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the mechanism of action of AMPs may help in the modification and development of AMPs. Many studies were conduc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ying Luo, Yuzhu Song
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antibiofilm anti-inflammatory antimicrobial antimicrobial peptides mechanism of action Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b6fffd33b3044b6e90f5ca946e902866
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b6fffd33b3044b6e90f5ca946e902866
record_format	dspace
spelling	oai:doaj.org-article:b6fffd33b3044b6e90f5ca946e9028662021-11-11T16:52:38ZMechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities10.3390/ijms2221114011422-00671661-6596https://doaj.org/article/b6fffd33b3044b6e90f5ca946e9028662021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11401https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the mechanism of action of AMPs may help in the modification and development of AMPs. Many studies were conducted on the mechanism of AMPs. The present review mainly summarizes the research status on the antimicrobial, anti-inflammatory, and antibiofilm properties of AMPs. This study not only describes the mechanism of cell wall action and membrane-targeting action but also includes the transmembrane mechanism of intracellular action and intracellular action targets. It also discusses the dual mechanism of action reported by a large number of investigations. Antibiofilm and anti-inflammatory mechanisms were described based on the formation of biofilms and inflammation. This study aims to provide a comprehensive review of the multiple activities and coordination of AMPs <i>in vivo</i>, and to fully understand AMPs to realize their therapeutic prospect.Ying LuoYuzhu SongMDPI AGarticleantibiofilmanti-inflammatoryantimicrobialantimicrobial peptidesmechanism of actionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11401, p 11401 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiofilm anti-inflammatory antimicrobial antimicrobial peptides mechanism of action Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	antibiofilm anti-inflammatory antimicrobial antimicrobial peptides mechanism of action Biology (General) QH301-705.5 Chemistry QD1-999 Ying Luo Yuzhu Song Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
description	Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the mechanism of action of AMPs may help in the modification and development of AMPs. Many studies were conducted on the mechanism of AMPs. The present review mainly summarizes the research status on the antimicrobial, anti-inflammatory, and antibiofilm properties of AMPs. This study not only describes the mechanism of cell wall action and membrane-targeting action but also includes the transmembrane mechanism of intracellular action and intracellular action targets. It also discusses the dual mechanism of action reported by a large number of investigations. Antibiofilm and anti-inflammatory mechanisms were described based on the formation of biofilms and inflammation. This study aims to provide a comprehensive review of the multiple activities and coordination of AMPs <i>in vivo</i>, and to fully understand AMPs to realize their therapeutic prospect.
format	article
author	Ying Luo Yuzhu Song
author_facet	Ying Luo Yuzhu Song
author_sort	Ying Luo
title	Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
title_short	Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
title_full	Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
title_fullStr	Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
title_full_unstemmed	Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
title_sort	mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b6fffd33b3044b6e90f5ca946e902866
work_keys_str_mv	AT yingluo mechanismofantimicrobialpeptidesantimicrobialantiinflammatoryandantibiofilmactivities AT yuzhusong mechanismofantimicrobialpeptidesantimicrobialantiinflammatoryandantibiofilmactivities
_version_	1718432260497080320

Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

Ejemplares similares