Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs

Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally distinct sfRNA classes in flaviviruses.

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Autores principales:	Andrea MacFadden, Zoe O’Donoghue, Patricia A. G. C. Silva, Erich G. Chapman, René C. Olsthoorn, Mark G. Sterken, Gorben P. Pijlman, Peter J. Bredenbeek, Jeffrey S. Kieft
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7039c42c77c4ec68cc74cfb0a5e0764
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spelling	oai:doaj.org-article:b7039c42c77c4ec68cc74cfb0a5e07642021-12-02T17:33:05ZMechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs10.1038/s41467-017-02604-y2041-1723https://doaj.org/article/b7039c42c77c4ec68cc74cfb0a5e07642018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02604-yhttps://doaj.org/toc/2041-1723Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally distinct sfRNA classes in flaviviruses.Andrea MacFaddenZoe O’DonoghuePatricia A. G. C. SilvaErich G. ChapmanRené C. OlsthoornMark G. SterkenGorben P. PijlmanPeter J. BredenbeekJeffrey S. KieftNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea MacFadden Zoe O’Donoghue Patricia A. G. C. Silva Erich G. Chapman René C. Olsthoorn Mark G. Sterken Gorben P. Pijlman Peter J. Bredenbeek Jeffrey S. Kieft Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
description	Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally distinct sfRNA classes in flaviviruses.
format	article
author	Andrea MacFadden Zoe O’Donoghue Patricia A. G. C. Silva Erich G. Chapman René C. Olsthoorn Mark G. Sterken Gorben P. Pijlman Peter J. Bredenbeek Jeffrey S. Kieft
author_facet	Andrea MacFadden Zoe O’Donoghue Patricia A. G. C. Silva Erich G. Chapman René C. Olsthoorn Mark G. Sterken Gorben P. Pijlman Peter J. Bredenbeek Jeffrey S. Kieft
author_sort	Andrea MacFadden
title	Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
title_short	Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
title_full	Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
title_fullStr	Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
title_full_unstemmed	Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs
title_sort	mechanism and structural diversity of exoribonuclease-resistant rna structures in flaviviral rnas
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b7039c42c77c4ec68cc74cfb0a5e0764
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Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs

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