Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice

Abstract The anti-bone resorptive drugs denosumab, an anti-human-RANKL antibody, and zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, have recently been applied for treatment of pediatric patients with bone diseases, though details regarding their effects in growing children have yet to...

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Autores principales:	Motoki Isawa, Akiko Karakawa, Nobuhiro Sakai, Saki Nishina, Miku Kuritani, Masahiro Chatani, Takako Negishi-Koga, Masashi Sato, Mitsuko Inoue, Yukie Shimada, Masamichi Takami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b70533e1eb9249e487693f5b7a41ef4c
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spelling	oai:doaj.org-article:b70533e1eb9249e487693f5b7a41ef4c2021-12-02T13:34:55ZBiological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice10.1038/s41598-019-56151-12045-2322https://doaj.org/article/b70533e1eb9249e487693f5b7a41ef4c2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56151-1https://doaj.org/toc/2045-2322Abstract The anti-bone resorptive drugs denosumab, an anti-human-RANKL antibody, and zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, have recently been applied for treatment of pediatric patients with bone diseases, though details regarding their effects in growing children have yet to be fully elucidated. In the present study, we administered these anti-resorptive drugs to mice from the age of 1 week and continued once-weekly injections for a total of 7 times. Mice that received the anti-RANKL antibody displayed normal growth and tooth eruption, though osteopetrotic bone volume gain in long and alveolar bones was noted, while there were nearly no osteoclasts and a normal of number osteoblasts observed. In contrast, ZOL significantly delayed body growth, tooth root formation, and tooth eruption, with increased osteoclast and decreased osteoblast numbers. These findings suggest regulation of tooth eruption via osteoblast differentiation by some types of anti-resorptive drugs.Motoki IsawaAkiko KarakawaNobuhiro SakaiSaki NishinaMiku KuritaniMasahiro ChataniTakako Negishi-KogaMasashi SatoMitsuko InoueYukie ShimadaMasamichi TakamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Motoki Isawa Akiko Karakawa Nobuhiro Sakai Saki Nishina Miku Kuritani Masahiro Chatani Takako Negishi-Koga Masashi Sato Mitsuko Inoue Yukie Shimada Masamichi Takami Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice
description	Abstract The anti-bone resorptive drugs denosumab, an anti-human-RANKL antibody, and zoledronic acid (ZOL), a nitrogen-containing bisphosphonate, have recently been applied for treatment of pediatric patients with bone diseases, though details regarding their effects in growing children have yet to be fully elucidated. In the present study, we administered these anti-resorptive drugs to mice from the age of 1 week and continued once-weekly injections for a total of 7 times. Mice that received the anti-RANKL antibody displayed normal growth and tooth eruption, though osteopetrotic bone volume gain in long and alveolar bones was noted, while there were nearly no osteoclasts and a normal of number osteoblasts observed. In contrast, ZOL significantly delayed body growth, tooth root formation, and tooth eruption, with increased osteoclast and decreased osteoblast numbers. These findings suggest regulation of tooth eruption via osteoblast differentiation by some types of anti-resorptive drugs.
format	article
author	Motoki Isawa Akiko Karakawa Nobuhiro Sakai Saki Nishina Miku Kuritani Masahiro Chatani Takako Negishi-Koga Masashi Sato Mitsuko Inoue Yukie Shimada Masamichi Takami
author_facet	Motoki Isawa Akiko Karakawa Nobuhiro Sakai Saki Nishina Miku Kuritani Masahiro Chatani Takako Negishi-Koga Masashi Sato Mitsuko Inoue Yukie Shimada Masamichi Takami
author_sort	Motoki Isawa
title	Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice
title_short	Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice
title_full	Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice
title_fullStr	Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice
title_full_unstemmed	Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice
title_sort	biological effects of anti-rankl antibody and zoledronic acid on growth and tooth eruption in growing mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b70533e1eb9249e487693f5b7a41ef4c
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Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice

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