The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland

Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant...

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Autores principales:	Maria Overvad, Lars Jorge Diaz, Peter Bjerregaard, Michael Lynge Pedersen, Christina Viskum Lytken Larsen, Ninna Senftleber, Niels Grarup, Torben Hansen, Marit Eika Jørgensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7078b340f8c4ce48c137ac95eaee21d
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spelling	oai:doaj.org-article:b7078b340f8c4ce48c137ac95eaee21d2021-12-02T11:57:56ZThe effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland10.1038/s41598-020-79132-12045-2322https://doaj.org/article/b7078b340f8c4ce48c137ac95eaee21d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79132-1https://doaj.org/toc/2045-2322Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models.Maria OvervadLars Jorge DiazPeter BjerregaardMichael Lynge PedersenChristina Viskum Lytken LarsenNinna SenftleberNiels GrarupTorben HansenMarit Eika JørgensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Overvad Lars Jorge Diaz Peter Bjerregaard Michael Lynge Pedersen Christina Viskum Lytken Larsen Ninna Senftleber Niels Grarup Torben Hansen Marit Eika Jørgensen The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
description	Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models.
format	article
author	Maria Overvad Lars Jorge Diaz Peter Bjerregaard Michael Lynge Pedersen Christina Viskum Lytken Larsen Ninna Senftleber Niels Grarup Torben Hansen Marit Eika Jørgensen
author_facet	Maria Overvad Lars Jorge Diaz Peter Bjerregaard Michael Lynge Pedersen Christina Viskum Lytken Larsen Ninna Senftleber Niels Grarup Torben Hansen Marit Eika Jørgensen
author_sort	Maria Overvad
title	The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
title_short	The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
title_full	The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
title_fullStr	The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
title_full_unstemmed	The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
title_sort	effect of diabetes and the common diabetogenic tbc1d4 p.arg684ter variant on cardiovascular risk in inuit in greenland
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b7078b340f8c4ce48c137ac95eaee21d
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The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland

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