Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).

<h4>Purpose</h4>To suggest the safety and efficacy of preservative-free triamcinolone acetonide intravitreal injectable suspension (Taioftal) for the treatment of diabetic macular edema.<h4>Methods</h4>A prospective clinical study involved 49 patients (49 eyes), that were tre...

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Autores principales:	Francesco Saverio Sorrentino, Claudio Bonifazzi, Francesco Parmeggiani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7078e8deac0445fb1ee23bdbceee017
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spelling	oai:doaj.org-article:b7078e8deac0445fb1ee23bdbceee0172021-12-02T20:17:26ZDiabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).1932-620310.1371/journal.pone.0257695https://doaj.org/article/b7078e8deac0445fb1ee23bdbceee0172021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257695https://doaj.org/toc/1932-6203<h4>Purpose</h4>To suggest the safety and efficacy of preservative-free triamcinolone acetonide intravitreal injectable suspension (Taioftal) for the treatment of diabetic macular edema.<h4>Methods</h4>A prospective clinical study involved 49 patients (49 eyes), that were treated with Taioftal and followed-up for six months. Complete ophthalmic examination, including spectral domain optical coherence tomography, was performed at baseline, and at month 1, 3, 6 after the intravitreal injection. Accurate collection and analysis of best-corrected visual acuity (BCVA), central foveal thickness (CFT), intraocular pressure (IOP), and adverse events (AEs) were carried out in order to evaluate visual function and macular morphology before and after treatment.<h4>Results</h4>Median BCVA value chosen as comparing statistics was significantly improved at every follow-up time points (gain of 6 letters at month 1, 12 at month 3 -improvement up to 24% at month 3 with stabilization until month 6) compared to baseline, as certified by Kruskal-Wallis rank sum test (P<0.05). Median CFT significantly waned at each follow-up times (decrease of about 65 μm at month 1, 155 at month 3 -reduction up to 28% at month 3 keeping good outcome until month 6) compared to baseline (P<0.05). IOP elevation, with no severe increases, was the most common among spotted AEs (median of 23 mmHg at month 1, 20 at month 3).<h4>Conclusion</h4>Intravitreal injection of preservative-free triamcinolone (Taioftal) is an effective, safe and inexpensive drug used to improve visual acuity and reduce central foveal thickness in eyes affected by diabetic macular edema during an average time of 6 months. Temporary, never severe, elevation of IOP is totally manageable with topical medications. No serious vision-threatening complications are related to the use of intravitreal triamcinolone injections.Francesco Saverio SorrentinoClaudio BonifazziFrancesco ParmeggianiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257695 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francesco Saverio Sorrentino Claudio Bonifazzi Francesco Parmeggiani Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).
description	<h4>Purpose</h4>To suggest the safety and efficacy of preservative-free triamcinolone acetonide intravitreal injectable suspension (Taioftal) for the treatment of diabetic macular edema.<h4>Methods</h4>A prospective clinical study involved 49 patients (49 eyes), that were treated with Taioftal and followed-up for six months. Complete ophthalmic examination, including spectral domain optical coherence tomography, was performed at baseline, and at month 1, 3, 6 after the intravitreal injection. Accurate collection and analysis of best-corrected visual acuity (BCVA), central foveal thickness (CFT), intraocular pressure (IOP), and adverse events (AEs) were carried out in order to evaluate visual function and macular morphology before and after treatment.<h4>Results</h4>Median BCVA value chosen as comparing statistics was significantly improved at every follow-up time points (gain of 6 letters at month 1, 12 at month 3 -improvement up to 24% at month 3 with stabilization until month 6) compared to baseline, as certified by Kruskal-Wallis rank sum test (P<0.05). Median CFT significantly waned at each follow-up times (decrease of about 65 μm at month 1, 155 at month 3 -reduction up to 28% at month 3 keeping good outcome until month 6) compared to baseline (P<0.05). IOP elevation, with no severe increases, was the most common among spotted AEs (median of 23 mmHg at month 1, 20 at month 3).<h4>Conclusion</h4>Intravitreal injection of preservative-free triamcinolone (Taioftal) is an effective, safe and inexpensive drug used to improve visual acuity and reduce central foveal thickness in eyes affected by diabetic macular edema during an average time of 6 months. Temporary, never severe, elevation of IOP is totally manageable with topical medications. No serious vision-threatening complications are related to the use of intravitreal triamcinolone injections.
format	article
author	Francesco Saverio Sorrentino Claudio Bonifazzi Francesco Parmeggiani
author_facet	Francesco Saverio Sorrentino Claudio Bonifazzi Francesco Parmeggiani
author_sort	Francesco Saverio Sorrentino
title	Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).
title_short	Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).
title_full	Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).
title_fullStr	Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).
title_full_unstemmed	Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).
title_sort	diabetic macular edema: safe and effective treatment with intravitreal triamcinolone acetonide (taioftal).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b7078e8deac0445fb1ee23bdbceee017
work_keys_str_mv	AT francescosaveriosorrentino diabeticmacularedemasafeandeffectivetreatmentwithintravitrealtriamcinoloneacetonidetaioftal AT claudiobonifazzi diabeticmacularedemasafeandeffectivetreatmentwithintravitrealtriamcinoloneacetonidetaioftal AT francescoparmeggiani diabeticmacularedemasafeandeffectivetreatmentwithintravitrealtriamcinoloneacetonidetaioftal
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Diabetic macular edema: Safe and effective treatment with intravitreal triamcinolone acetonide (Taioftal).

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