Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.

<h4>Background</h4>Casein kinase 1 delta (CK1delta) phosphorylates many key proteins playing important roles in such biological processes as cell growth, differentiation, apoptosis, circadian rhythm and vesicle transport. Furthermore, deregulation of CK1delta has been linked to neurodege...

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Autores principales:	Jürgen Löhler, Heidrun Hirner, Bernhard Schmidt, Klaus Kramer, Dietmar Fischer, Dietmar R Thal, Frank Leithäuser, Uwe Knippschild
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b70796d713fc4b4a92b4b3c74e7b4dc3
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spelling	oai:doaj.org-article:b70796d713fc4b4a92b4b3c74e7b4dc32021-11-25T06:17:48ZImmunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.1932-620310.1371/journal.pone.0004174https://doaj.org/article/b70796d713fc4b4a92b4b3c74e7b4dc32009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19137063/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Casein kinase 1 delta (CK1delta) phosphorylates many key proteins playing important roles in such biological processes as cell growth, differentiation, apoptosis, circadian rhythm and vesicle transport. Furthermore, deregulation of CK1delta has been linked to neurodegenerative diseases and cancer. In this study, the cell specific distribution of CK1delta in various tissues and organs of young adult BALB/c mice was analysed by immunohistochemistry.<h4>Methodology/principal findings</h4>Immunohistochemical staining of CK1delta was performed using three different antibodies against CK1delta. A high expression of CK1delta was found in a variety of tissues and organ systems and in several cell types of endodermal, mesodermal and ectodermal origin.<h4>Conclusions</h4>These results give an overview of the cell-type specific expression of CK1delta in different organs under normal conditions. Thus, they provide evidence for possible cell-type specific functions of CK1delta, where CK1delta can interact with and modulate the activity of key regulator proteins by site directed phosphorylation. Furthermore, they provide the basis for future analyses of CK1delta in these tissues.Jürgen LöhlerHeidrun HirnerBernhard SchmidtKlaus KramerDietmar FischerDietmar R ThalFrank LeithäuserUwe KnippschildPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 1, p e4174 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jürgen Löhler Heidrun Hirner Bernhard Schmidt Klaus Kramer Dietmar Fischer Dietmar R Thal Frank Leithäuser Uwe Knippschild Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
description	<h4>Background</h4>Casein kinase 1 delta (CK1delta) phosphorylates many key proteins playing important roles in such biological processes as cell growth, differentiation, apoptosis, circadian rhythm and vesicle transport. Furthermore, deregulation of CK1delta has been linked to neurodegenerative diseases and cancer. In this study, the cell specific distribution of CK1delta in various tissues and organs of young adult BALB/c mice was analysed by immunohistochemistry.<h4>Methodology/principal findings</h4>Immunohistochemical staining of CK1delta was performed using three different antibodies against CK1delta. A high expression of CK1delta was found in a variety of tissues and organ systems and in several cell types of endodermal, mesodermal and ectodermal origin.<h4>Conclusions</h4>These results give an overview of the cell-type specific expression of CK1delta in different organs under normal conditions. Thus, they provide evidence for possible cell-type specific functions of CK1delta, where CK1delta can interact with and modulate the activity of key regulator proteins by site directed phosphorylation. Furthermore, they provide the basis for future analyses of CK1delta in these tissues.
format	article
author	Jürgen Löhler Heidrun Hirner Bernhard Schmidt Klaus Kramer Dietmar Fischer Dietmar R Thal Frank Leithäuser Uwe Knippschild
author_facet	Jürgen Löhler Heidrun Hirner Bernhard Schmidt Klaus Kramer Dietmar Fischer Dietmar R Thal Frank Leithäuser Uwe Knippschild
author_sort	Jürgen Löhler
title	Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
title_short	Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
title_full	Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
title_fullStr	Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
title_full_unstemmed	Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.
title_sort	immunohistochemical characterisation of cell-type specific expression of ck1delta in various tissues of young adult balb/c mice.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/b70796d713fc4b4a92b4b3c74e7b4dc3
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Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice.

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