Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.

Cross-reactivity of Fusarium species with serum galactomannan antigen (GMI) test has been observed. We sought to evaluate if GMI could help to early diagnose invasive fusariosis and to monitor treatment response. We reviewed the records of all patients with invasive fusariosis between 2008 and 2012...

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Autores principales: Marcio Nucci, Fabianne Carlesse, Paola Cappellano, Andrea G Varon, Adriana Seber, Marcia Garnica, Simone A Nouér, Arnaldo L Colombo
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:b709290f266e4f5885409f7229453c442021-11-18T08:35:15ZEarlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.1932-620310.1371/journal.pone.0087784https://doaj.org/article/b709290f266e4f5885409f7229453c442014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24489964/?tool=EBIhttps://doaj.org/toc/1932-6203Cross-reactivity of Fusarium species with serum galactomannan antigen (GMI) test has been observed. We sought to evaluate if GMI could help to early diagnose invasive fusariosis and to monitor treatment response. We reviewed the records of all patients with invasive fusariosis between 2008 and 2012 in three Brazilian hospitals. We selected patients who had at least 1 GMI test within 2 days before or after the date of the first clinical manifestation of fusariosis, and analyzed the temporal relationship between the first positive GMI test and the date of the diagnosis of invasive fusariosis, and the kinetics of GMI in relation to patients' response to treatment. We also selected 18 controls to determine the sensitivity and specificity of the test. Among 18 patients, 15 (83%) had at least one positive GMI (median 4, range 1-15). The sensitivity and specificity of was 83% and 67%, respectively. GMI was positive before the diagnosis of invasive fusariosis in 11 of the 15 cases (73%), at a median of 10 days (range 3-39), and after the diagnosis in 4 cases. GMI became negative in 8 of the 15 patients; 3 of these 8 patients (37.5%) were alive 90 days after the diagnosis of fusariosis compared with 2 of 7 (29%) who did not normalize GMI (p = 1.0). GMI is frequently positive in invasive fusariosis, and becomes positive before diagnosis in most patients. These findings may have important implications for the choice of antifungal therapy in settings with high prevalence of invasive fusariosis.Marcio NucciFabianne CarlessePaola CappellanoAndrea G VaronAdriana SeberMarcia GarnicaSimone A NouérArnaldo L ColomboPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87784 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Marcio Nucci
Fabianne Carlesse
Paola Cappellano
Andrea G Varon
Adriana Seber
Marcia Garnica
Simone A Nouér
Arnaldo L Colombo
Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.
description Cross-reactivity of Fusarium species with serum galactomannan antigen (GMI) test has been observed. We sought to evaluate if GMI could help to early diagnose invasive fusariosis and to monitor treatment response. We reviewed the records of all patients with invasive fusariosis between 2008 and 2012 in three Brazilian hospitals. We selected patients who had at least 1 GMI test within 2 days before or after the date of the first clinical manifestation of fusariosis, and analyzed the temporal relationship between the first positive GMI test and the date of the diagnosis of invasive fusariosis, and the kinetics of GMI in relation to patients' response to treatment. We also selected 18 controls to determine the sensitivity and specificity of the test. Among 18 patients, 15 (83%) had at least one positive GMI (median 4, range 1-15). The sensitivity and specificity of was 83% and 67%, respectively. GMI was positive before the diagnosis of invasive fusariosis in 11 of the 15 cases (73%), at a median of 10 days (range 3-39), and after the diagnosis in 4 cases. GMI became negative in 8 of the 15 patients; 3 of these 8 patients (37.5%) were alive 90 days after the diagnosis of fusariosis compared with 2 of 7 (29%) who did not normalize GMI (p = 1.0). GMI is frequently positive in invasive fusariosis, and becomes positive before diagnosis in most patients. These findings may have important implications for the choice of antifungal therapy in settings with high prevalence of invasive fusariosis.
format article
author Marcio Nucci
Fabianne Carlesse
Paola Cappellano
Andrea G Varon
Adriana Seber
Marcia Garnica
Simone A Nouér
Arnaldo L Colombo
author_facet Marcio Nucci
Fabianne Carlesse
Paola Cappellano
Andrea G Varon
Adriana Seber
Marcia Garnica
Simone A Nouér
Arnaldo L Colombo
author_sort Marcio Nucci
title Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.
title_short Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.
title_full Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.
title_fullStr Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.
title_full_unstemmed Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing.
title_sort earlier diagnosis of invasive fusariosis with aspergillus serum galactomannan testing.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/b709290f266e4f5885409f7229453c44
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