Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer

Xin Jin, Qing Yang, Youwen Zhang Department of Hospital Pharmacy, Suqian Branch Jiangsu Province Hospital, Suzhilu, Suqian, People’s Republic of China Abstract: To develop an alternative treatment for lung cancer, a combination of two potent chemotherapeutic agents – liposomal...

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Autores principales:	Jin X, Yang Q, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	apigenin TPGS liposomes tyroservatide synergistic anti-tumor apoptosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b70aead511984e2295491a84d1ca71e8
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spelling	oai:doaj.org-article:b70aead511984e2295491a84d1ca71e82021-12-02T08:07:44ZSynergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer1178-2013https://doaj.org/article/b70aead511984e2295491a84d1ca71e82017-07-01T00:00:00Zhttps://www.dovepress.com/synergistic-apoptotic-effects-of-apigenin-tpgs-liposomes-and-tyroserva-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xin Jin, Qing Yang, Youwen Zhang Department of Hospital Pharmacy, Suqian Branch Jiangsu Province Hospital, Suzhilu, Suqian, People’s Republic of China Abstract: To develop an alternative treatment for lung cancer, a combination of two potent chemotherapeutic agents – liposomal apigenin and tyroservatide – was developed. The therapeutic potential of this combination was investigated using A549 cells. Apigenin and tocopherol derivative-containing D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) liposomes might improve the delivery of apigenin to tumor cells, both in vitro and in vivo. Importantly, compared to either agent alone, the combination of apigenin TPGS liposomes and tyroservatide exhibited superior cytotoxicity, induced stronger G2 arrest, and suppressed A549 cancer cell invasion at a lower dose. The proapoptotic synergistic effects were also observed in A549 cells using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, flow cytometry, and Western blot analysis. More importantly, in vivo results showed that the combination of apigenin TPGS liposomes and tyroservatide exhibited tumor-growth inhibitory effects in A549 cell-bearing mice. In conclusion, our study showed that this combination therapy could serve as a promising synergistic therapeutic approach to improve outcomes in patients with lung cancer. Keywords: apigenin, TPGS liposomes, tyroservatide, synergistic antitumor, apoptosis Jin XYang QZhang YDove Medical PressarticleapigeninTPGS liposomestyroservatidesynergistic anti-tumorapoptosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5109-5118 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	apigenin TPGS liposomes tyroservatide synergistic anti-tumor apoptosis Medicine (General) R5-920
spellingShingle	apigenin TPGS liposomes tyroservatide synergistic anti-tumor apoptosis Medicine (General) R5-920 Jin X Yang Q Zhang Y Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer
description	Xin Jin, Qing Yang, Youwen Zhang Department of Hospital Pharmacy, Suqian Branch Jiangsu Province Hospital, Suzhilu, Suqian, People’s Republic of China Abstract: To develop an alternative treatment for lung cancer, a combination of two potent chemotherapeutic agents – liposomal apigenin and tyroservatide – was developed. The therapeutic potential of this combination was investigated using A549 cells. Apigenin and tocopherol derivative-containing D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) liposomes might improve the delivery of apigenin to tumor cells, both in vitro and in vivo. Importantly, compared to either agent alone, the combination of apigenin TPGS liposomes and tyroservatide exhibited superior cytotoxicity, induced stronger G2 arrest, and suppressed A549 cancer cell invasion at a lower dose. The proapoptotic synergistic effects were also observed in A549 cells using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, flow cytometry, and Western blot analysis. More importantly, in vivo results showed that the combination of apigenin TPGS liposomes and tyroservatide exhibited tumor-growth inhibitory effects in A549 cell-bearing mice. In conclusion, our study showed that this combination therapy could serve as a promising synergistic therapeutic approach to improve outcomes in patients with lung cancer. Keywords: apigenin, TPGS liposomes, tyroservatide, synergistic antitumor, apoptosis
format	article
author	Jin X Yang Q Zhang Y
author_facet	Jin X Yang Q Zhang Y
author_sort	Jin X
title	Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer
title_short	Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer
title_full	Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer
title_fullStr	Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer
title_full_unstemmed	Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer
title_sort	synergistic apoptotic effects of apigenin tpgs liposomes and tyroservatide: implications for effective treatment of lung cancer
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/b70aead511984e2295491a84d1ca71e8
work_keys_str_mv	AT jinx synergisticapoptoticeffectsofapigenintpgsliposomesandtyroservatideimplicationsforeffectivetreatmentoflungcancer AT yangq synergisticapoptoticeffectsofapigenintpgsliposomesandtyroservatideimplicationsforeffectivetreatmentoflungcancer AT zhangy synergisticapoptoticeffectsofapigenintpgsliposomesandtyroservatideimplicationsforeffectivetreatmentoflungcancer
_version_	1718398682590609408

Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer

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