Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis

Abstract The efficacy and safety of misoprostol alone for missed abortion varied with different regimens. To evaluate existing evidence for the medical management of missed abortion using misoprostol, we undertook a comprehensive review and meta-analysis. The electronic literature search was conduct...

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Autores principales:	Hang-lin Wu, Sheeba Marwah, Pei Wang, Qiu-meng Wang, Xiao-wen Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b70cb7bf60c74ef08b7c7f5207141403
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spelling	oai:doaj.org-article:b70cb7bf60c74ef08b7c7f52071414032021-12-02T16:08:20ZMisoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis10.1038/s41598-017-01892-02045-2322https://doaj.org/article/b70cb7bf60c74ef08b7c7f52071414032017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01892-0https://doaj.org/toc/2045-2322Abstract The efficacy and safety of misoprostol alone for missed abortion varied with different regimens. To evaluate existing evidence for the medical management of missed abortion using misoprostol, we undertook a comprehensive review and meta-analysis. The electronic literature search was conducted using PubMed, the Cochrane Library, Embase, EBSCOhost Online Research Databases, Springer Link, ScienceDirect, Web of Science, Ovid Medline and Google Scholar. 18 studies of 1802 participants were included in our analysis. Compared with vaginal misoprostol of 800 ug or sublingual misoprostol of 600 ug, lower-dose regimens (200 ug or 400 ug) by any route of administration tend to be significantly less effective in producing abortion within about 24 hours. In terms of efficacy, the most effective treatment was sublingual misoprostol of 600 ug and the least effective was oral misoprostol of 400 ug. In terms of tolerability, vaginal misoprostol of 400 ug was reported with fewer side effects and sublingual misoprostol of 600 ug was reported with more side effects. Misoprostol is a non-invasive, effective medical method for completion of abortion in missed abortion. Sublingual misoprostol of 600 ug or vaginal misoprostol of 800 ug may be a good choice for the first dose. The ideal dose and medication interval of misoprostol however needs to be further researched.Hang-lin WuSheeba MarwahPei WangQiu-meng WangXiao-wen ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hang-lin Wu Sheeba Marwah Pei Wang Qiu-meng Wang Xiao-wen Chen Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
description	Abstract The efficacy and safety of misoprostol alone for missed abortion varied with different regimens. To evaluate existing evidence for the medical management of missed abortion using misoprostol, we undertook a comprehensive review and meta-analysis. The electronic literature search was conducted using PubMed, the Cochrane Library, Embase, EBSCOhost Online Research Databases, Springer Link, ScienceDirect, Web of Science, Ovid Medline and Google Scholar. 18 studies of 1802 participants were included in our analysis. Compared with vaginal misoprostol of 800 ug or sublingual misoprostol of 600 ug, lower-dose regimens (200 ug or 400 ug) by any route of administration tend to be significantly less effective in producing abortion within about 24 hours. In terms of efficacy, the most effective treatment was sublingual misoprostol of 600 ug and the least effective was oral misoprostol of 400 ug. In terms of tolerability, vaginal misoprostol of 400 ug was reported with fewer side effects and sublingual misoprostol of 600 ug was reported with more side effects. Misoprostol is a non-invasive, effective medical method for completion of abortion in missed abortion. Sublingual misoprostol of 600 ug or vaginal misoprostol of 800 ug may be a good choice for the first dose. The ideal dose and medication interval of misoprostol however needs to be further researched.
format	article
author	Hang-lin Wu Sheeba Marwah Pei Wang Qiu-meng Wang Xiao-wen Chen
author_facet	Hang-lin Wu Sheeba Marwah Pei Wang Qiu-meng Wang Xiao-wen Chen
author_sort	Hang-lin Wu
title	Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
title_short	Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
title_full	Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
title_fullStr	Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
title_full_unstemmed	Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
title_sort	misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b70cb7bf60c74ef08b7c7f5207141403
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Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis

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