High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Zhihua Liu, Yan Cai, Jincai He Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Purpose: Although previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidat...

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Autores principales:	Liu ZH, Cai Y, He J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	oxidative stress 8-hydroxy-2′-deoxyguanosine catalase depression stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b71463da07a34dbfa7d2676313c24491
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spelling	oai:doaj.org-article:b71463da07a34dbfa7d2676313c244912021-12-02T02:55:04ZHigh serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors1178-2021https://doaj.org/article/b71463da07a34dbfa7d2676313c244912018-02-01T00:00:00Zhttps://www.dovepress.com/high-serum-levels-of-8-ohdg-are-an-independent-predictor-of-post-strok-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zhihua Liu, Yan Cai, Jincai He Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Purpose: Although previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidative deoxyribonucleic acid damage and post-stroke depression (PSD) remains unelucidated. Patients and methods: Two hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up at 1 month. Serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) and catalase (CAT) levels were measured within 24 h of admission using a commercially available enzyme-linked immunosorbent assay. The 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Diagnosis of PSD was made in line with the Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for depression. Results: Serum levels of 8-OHdG (P<0.001) and CAT (P=0.025) increased in depressed patients at admission. A positive correlation was found between the 8-OHdG and CAT levels in both the total stroke patients (r=0.320, P<0.001) and the depressed patients (r=0.300, P=0.012). The 8-OHdG levels were positively correlated with the 17-item Hamilton Depression Scale scores (r=0.129, P=0.046) in depressed patients. Multivariate analyses found that 8-OHdG levels ≥200.0 ng/L were independently associated with PSD (odds ratio, 7.477; 95% CI, 3.342–16.289, P<0.001) after adjusting for possible relevant confounders. Conclusion: Higher serum 8-OHdG levels at admission were found to be correlated with PSD 1 month after stroke. Keywords: oxidative stress, 8-hydroxy-2'-deoxyguanosine, catalase, depression, strokeLiu ZHCai YHe JDove Medical Pressarticleoxidative stress8-hydroxy-2′-deoxyguanosinecatalasedepressionstrokeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 587-596 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress 8-hydroxy-2′-deoxyguanosine catalase depression stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	oxidative stress 8-hydroxy-2′-deoxyguanosine catalase depression stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu ZH Cai Y He J High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
description	Zhihua Liu, Yan Cai, Jincai He Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Purpose: Although previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidative deoxyribonucleic acid damage and post-stroke depression (PSD) remains unelucidated. Patients and methods: Two hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up at 1 month. Serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) and catalase (CAT) levels were measured within 24 h of admission using a commercially available enzyme-linked immunosorbent assay. The 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Diagnosis of PSD was made in line with the Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for depression. Results: Serum levels of 8-OHdG (P<0.001) and CAT (P=0.025) increased in depressed patients at admission. A positive correlation was found between the 8-OHdG and CAT levels in both the total stroke patients (r=0.320, P<0.001) and the depressed patients (r=0.300, P=0.012). The 8-OHdG levels were positively correlated with the 17-item Hamilton Depression Scale scores (r=0.129, P=0.046) in depressed patients. Multivariate analyses found that 8-OHdG levels ≥200.0 ng/L were independently associated with PSD (odds ratio, 7.477; 95% CI, 3.342–16.289, P<0.001) after adjusting for possible relevant confounders. Conclusion: Higher serum 8-OHdG levels at admission were found to be correlated with PSD 1 month after stroke. Keywords: oxidative stress, 8-hydroxy-2'-deoxyguanosine, catalase, depression, stroke
format	article
author	Liu ZH Cai Y He J
author_facet	Liu ZH Cai Y He J
author_sort	Liu ZH
title	High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
title_short	High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
title_full	High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
title_fullStr	High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
title_full_unstemmed	High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors
title_sort	high serum levels of 8-ohdg are an independent predictor of post-stroke depression in chinese stroke survivors
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b71463da07a34dbfa7d2676313c24491
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High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

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