Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension

Relevance.Diastolic chronic heart failure (CHF) is a characteristic complication of essential hypertension (EH). Materials and methods.62 females with EH were examined. The first group (n=47, mean age 51.56.2 years) persons with EH complicated by diastolic CHF, the second group (n=15, 49.86.7 ye...

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Autores principales:	Anton V. Barsukov, Alla Yu. Seidova, Ksenia A. Shcherbakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Concilium Medicum 2020
Materias:	essential hypertension diastolic chronic heart failure cardiovascular system metabolism proinflammatory status correlation analysis female gender Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/b715a57c041a4f4185991b4c10533a47
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spelling	oai:doaj.org-article:b715a57c041a4f4185991b4c10533a472021-12-01T22:07:01ZInfluence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension2221-71852658-570710.26442/22217185.2020.1.200099https://doaj.org/article/b715a57c041a4f4185991b4c10533a472020-09-01T00:00:00Zhttps://cardiosomatics.orscience.ru/2221-7185/article/viewFile/46035/31038https://doaj.org/toc/2221-7185https://doaj.org/toc/2658-5707Relevance.Diastolic chronic heart failure (CHF) is a characteristic complication of essential hypertension (EH). Materials and methods.62 females with EH were examined. The first group (n=47, mean age 51.56.2 years) persons with EH complicated by diastolic CHF, the second group (n=15, 49.86.7 years) persons with uncomplicated EH. The diagnosis of CHF in females of the first group is confirmed by the data of the test with 6-minute walking, increased blood content of the N-terminal precursor of the brain natriuretic peptide, the presence of left atrial dilatation, hypertrophy and disturbed left ventricle (LV) relaxation. The levels of indices of lipid, carbohydrate, purine metabolism, mediators of systemic inflammation (С-reactive protein), tumor necrosis factor alpha (TNF-a), interleukin-6 (IL-6) were studied and a correlation analysis of the whole set of laboratory data with 6-minute walking test results and an integral index of diastolic LV dysfunction (E/e). Results. Females with EH complicated initial manifestations of diastolic heart failure, characterized by significantly higher, but the corresponding values of the reference range, the content in blood TNF-a, IL-6 compared with females with uncomplicated EH. In females with hypertension complicated initial manifestations of diastolic heart failure is established significant correlation between blood levels of atherogenic lipids and lipoproteins, glucose, uric acid, CRP, TNF-a, IL-6 on the one hand and indices characterizing reduced tolerance to physical load, diastolic LV dysfunction. Conclusion.Formation of diastolic heart failure clinical syndrome as well as disturbances of LV relax function in hypertensive females allows participation of metabolic factors and pro-inflammatory pattern.Anton V. BarsukovAlla Yu. SeidovaKsenia A. ShcherbakovaConcilium Medicumarticleessential hypertensiondiastolic chronic heart failurecardiovascular systemmetabolismproinflammatory statuscorrelation analysisfemale genderDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUКардиоСоматика, Vol 11, Iss 1, Pp 16-22 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	essential hypertension diastolic chronic heart failure cardiovascular system metabolism proinflammatory status correlation analysis female gender Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	essential hypertension diastolic chronic heart failure cardiovascular system metabolism proinflammatory status correlation analysis female gender Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Anton V. Barsukov Alla Yu. Seidova Ksenia A. Shcherbakova Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension
description	Relevance.Diastolic chronic heart failure (CHF) is a characteristic complication of essential hypertension (EH). Materials and methods.62 females with EH were examined. The first group (n=47, mean age 51.56.2 years) persons with EH complicated by diastolic CHF, the second group (n=15, 49.86.7 years) persons with uncomplicated EH. The diagnosis of CHF in females of the first group is confirmed by the data of the test with 6-minute walking, increased blood content of the N-terminal precursor of the brain natriuretic peptide, the presence of left atrial dilatation, hypertrophy and disturbed left ventricle (LV) relaxation. The levels of indices of lipid, carbohydrate, purine metabolism, mediators of systemic inflammation (С-reactive protein), tumor necrosis factor alpha (TNF-a), interleukin-6 (IL-6) were studied and a correlation analysis of the whole set of laboratory data with 6-minute walking test results and an integral index of diastolic LV dysfunction (E/e). Results. Females with EH complicated initial manifestations of diastolic heart failure, characterized by significantly higher, but the corresponding values of the reference range, the content in blood TNF-a, IL-6 compared with females with uncomplicated EH. In females with hypertension complicated initial manifestations of diastolic heart failure is established significant correlation between blood levels of atherogenic lipids and lipoproteins, glucose, uric acid, CRP, TNF-a, IL-6 on the one hand and indices characterizing reduced tolerance to physical load, diastolic LV dysfunction. Conclusion.Formation of diastolic heart failure clinical syndrome as well as disturbances of LV relax function in hypertensive females allows participation of metabolic factors and pro-inflammatory pattern.
format	article
author	Anton V. Barsukov Alla Yu. Seidova Ksenia A. Shcherbakova
author_facet	Anton V. Barsukov Alla Yu. Seidova Ksenia A. Shcherbakova
author_sort	Anton V. Barsukov
title	Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension
title_short	Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension
title_full	Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension
title_fullStr	Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension
title_full_unstemmed	Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension
title_sort	influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension
publisher	Concilium Medicum
publishDate	2020
url	https://doaj.org/article/b715a57c041a4f4185991b4c10533a47
work_keys_str_mv	AT antonvbarsukov influenceofmetabolicandproinflammatoryfactorsondiastolicheartfailureformationinfemaleswithessentialhypertension AT allayuseidova influenceofmetabolicandproinflammatoryfactorsondiastolicheartfailureformationinfemaleswithessentialhypertension AT kseniaashcherbakova influenceofmetabolicandproinflammatoryfactorsondiastolicheartfailureformationinfemaleswithessentialhypertension
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Influence of metabolic and proinflammatory factors on diastolic heart failure formation in females with essential hypertension

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