Dermoscopic Aspects of Cutaneous Adverse Drug Reactions

Background: Little is known about the dermoscopic evaluation of cutaneous adverse drug reactions (CADRs). Objectives: To evaluate the dermoscopic patterns of CADRs and identify those associated with severe cutaneous adverse reactions to drugs (SCARDs). Patients and Methods: Patients included...

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Autores principales:	Gabriela Rossi, André da Silva Cartell, Renato Marchiori Bakos
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	cutaneous adverse drug reactions drug eruptions dermoscopic patterns dermoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/b718b94ae5894db3853dc5161df9d344
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spelling	oai:doaj.org-article:b718b94ae5894db3853dc5161df9d3442021-11-17T08:28:19ZDermoscopic Aspects of Cutaneous Adverse Drug Reactions10.5826/dpc.1101a1362160-9381https://doaj.org/article/b718b94ae5894db3853dc5161df9d3442021-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1296https://doaj.org/toc/2160-9381 Background: Little is known about the dermoscopic evaluation of cutaneous adverse drug reactions (CADRs). Objectives: To evaluate the dermoscopic patterns of CADRs and identify those associated with severe cutaneous adverse reactions to drugs (SCARDs). Patients and Methods: Patients included in this study from May 2015 to April 2016 had presented with CADRs. CADR presentation and classification were based on standard criteria. SCARDs included Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), overlap SJS/TEN, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP). The dermoscopic features of CADRs were described and compared according to the severity of the reactions. Results: Sixty-nine patients were included. Sixteen patients (23.2%) presented SCARDs. The main dermoscopic findings in SJS, overlap SJS/TEN and TEN were black dots or necrotic areas (100%). Erosion [respectively, 4/6 (66.7%), 3/3 (100%) and 1/1 (100%)], necrotic borders [respectively, 4/6 (66.7%), 3/3 (100%) and 1/1, (100%)] and epidermal detachment [respectively, 5/6 (83.3%); 2/3 (66.7%) and 1/1 (100%)] were also common among these reactions. Erythema and purpuric dots were the main dermoscopic findings [respectively, 5/6 (83.3%) and 4/6 (66.7%)] in DRESS. In non-severe reactions, the most prevalent structures were erythema and purpura in exanthema [respectively, 31/33 (93.9%) and 24/33 (72.7%)] and erythema and vascular structures in urticarial reactions [respectively, 6/6 (100%) and 3/6 (50%)]. Black dots or necrotic areas, epidermal detachment, necrotic borders and erosion were highly associated with SCARDs (P < 0.001). Conclusions: Dermoscopy improves clinical recognition of SCARDs. Gabriela RossiAndré da Silva CartellRenato Marchiori BakosMattioli1885articlecutaneous adverse drug reactionsdrug eruptionsdermoscopic patternsdermoscopyDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 11, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cutaneous adverse drug reactions drug eruptions dermoscopic patterns dermoscopy Dermatology RL1-803
spellingShingle	cutaneous adverse drug reactions drug eruptions dermoscopic patterns dermoscopy Dermatology RL1-803 Gabriela Rossi André da Silva Cartell Renato Marchiori Bakos Dermoscopic Aspects of Cutaneous Adverse Drug Reactions
description	Background: Little is known about the dermoscopic evaluation of cutaneous adverse drug reactions (CADRs). Objectives: To evaluate the dermoscopic patterns of CADRs and identify those associated with severe cutaneous adverse reactions to drugs (SCARDs). Patients and Methods: Patients included in this study from May 2015 to April 2016 had presented with CADRs. CADR presentation and classification were based on standard criteria. SCARDs included Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), overlap SJS/TEN, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP). The dermoscopic features of CADRs were described and compared according to the severity of the reactions. Results: Sixty-nine patients were included. Sixteen patients (23.2%) presented SCARDs. The main dermoscopic findings in SJS, overlap SJS/TEN and TEN were black dots or necrotic areas (100%). Erosion [respectively, 4/6 (66.7%), 3/3 (100%) and 1/1 (100%)], necrotic borders [respectively, 4/6 (66.7%), 3/3 (100%) and 1/1, (100%)] and epidermal detachment [respectively, 5/6 (83.3%); 2/3 (66.7%) and 1/1 (100%)] were also common among these reactions. Erythema and purpuric dots were the main dermoscopic findings [respectively, 5/6 (83.3%) and 4/6 (66.7%)] in DRESS. In non-severe reactions, the most prevalent structures were erythema and purpura in exanthema [respectively, 31/33 (93.9%) and 24/33 (72.7%)] and erythema and vascular structures in urticarial reactions [respectively, 6/6 (100%) and 3/6 (50%)]. Black dots or necrotic areas, epidermal detachment, necrotic borders and erosion were highly associated with SCARDs (P < 0.001). Conclusions: Dermoscopy improves clinical recognition of SCARDs.
format	article
author	Gabriela Rossi André da Silva Cartell Renato Marchiori Bakos
author_facet	Gabriela Rossi André da Silva Cartell Renato Marchiori Bakos
author_sort	Gabriela Rossi
title	Dermoscopic Aspects of Cutaneous Adverse Drug Reactions
title_short	Dermoscopic Aspects of Cutaneous Adverse Drug Reactions
title_full	Dermoscopic Aspects of Cutaneous Adverse Drug Reactions
title_fullStr	Dermoscopic Aspects of Cutaneous Adverse Drug Reactions
title_full_unstemmed	Dermoscopic Aspects of Cutaneous Adverse Drug Reactions
title_sort	dermoscopic aspects of cutaneous adverse drug reactions
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/b718b94ae5894db3853dc5161df9d344
work_keys_str_mv	AT gabrielarossi dermoscopicaspectsofcutaneousadversedrugreactions AT andredasilvacartell dermoscopicaspectsofcutaneousadversedrugreactions AT renatomarchioribakos dermoscopicaspectsofcutaneousadversedrugreactions
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Dermoscopic Aspects of Cutaneous Adverse Drug Reactions

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