New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports

Abstract Background Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodeficiency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is an enzyme originally found in Enterobacteriaceae. Case presentation...

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Autores principales:	Mahdane Roshani, Alireza Goodarzi, Sanaz Dehbashi, Farhad Afrasiabi, Hossein Goudarzi, Ali Hashemi, Mohammad Reza Arabestani
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	bla NDM-1 Escherichia coli Klebsiella pneumoniae Leukemia Medicine R
Acceso en línea:	https://doaj.org/article/b721fadf8fe244c7b0715b378308f370
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spelling	oai:doaj.org-article:b721fadf8fe244c7b0715b378308f3702021-11-28T12:37:22ZNew Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports10.1186/s13256-021-03160-21752-1947https://doaj.org/article/b721fadf8fe244c7b0715b378308f3702021-11-01T00:00:00Zhttps://doi.org/10.1186/s13256-021-03160-2https://doaj.org/toc/1752-1947Abstract Background Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodeficiency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is an enzyme originally found in Enterobacteriaceae. Case presentation In this study, 80 isolates of Escherichia coli and Klebsiella pneumoniae were collected over the course of 2 years from two medical centers in Tehran, Iran. Production of carbapenemase was detected in the isolates using modified Hodge test. New Delhi metallo-beta-lactamase-1 genes were detected by polymerase chain reaction amplification with specific primers. Two New Delhi metallo-beta-lactamase-1-producing Escherichia coli strains were isolated from two Iranian patients with leukemia. These two patients were 6 and 15 years old, one female and the other male, from two oncology centers in Iran. The isolates were resistant to carbapenems (imipenem, meropenem), and two isolates were positive for carbapenemase production by modified Hodge test. Conclusions The emergence of New Delhi metallo-beta-lactamase-1-producing Escherichia coli is a threat for leukemia patients in oncology and hematology departments. We conclude that the incidence of multidrug resistant pathogens has increased among patients with leukemia and is life threatening.Mahdane RoshaniAlireza GoodarziSanaz DehbashiFarhad AfrasiabiHossein GoudarziAli HashemiMohammad Reza ArabestaniBMCarticlebla NDM-1Escherichia coliKlebsiella pneumoniaeLeukemiaMedicineRENJournal of Medical Case Reports, Vol 15, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bla NDM-1 Escherichia coli Klebsiella pneumoniae Leukemia Medicine R
spellingShingle	bla NDM-1 Escherichia coli Klebsiella pneumoniae Leukemia Medicine R Mahdane Roshani Alireza Goodarzi Sanaz Dehbashi Farhad Afrasiabi Hossein Goudarzi Ali Hashemi Mohammad Reza Arabestani New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports
description	Abstract Background Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodeficiency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is an enzyme originally found in Enterobacteriaceae. Case presentation In this study, 80 isolates of Escherichia coli and Klebsiella pneumoniae were collected over the course of 2 years from two medical centers in Tehran, Iran. Production of carbapenemase was detected in the isolates using modified Hodge test. New Delhi metallo-beta-lactamase-1 genes were detected by polymerase chain reaction amplification with specific primers. Two New Delhi metallo-beta-lactamase-1-producing Escherichia coli strains were isolated from two Iranian patients with leukemia. These two patients were 6 and 15 years old, one female and the other male, from two oncology centers in Iran. The isolates were resistant to carbapenems (imipenem, meropenem), and two isolates were positive for carbapenemase production by modified Hodge test. Conclusions The emergence of New Delhi metallo-beta-lactamase-1-producing Escherichia coli is a threat for leukemia patients in oncology and hematology departments. We conclude that the incidence of multidrug resistant pathogens has increased among patients with leukemia and is life threatening.
format	article
author	Mahdane Roshani Alireza Goodarzi Sanaz Dehbashi Farhad Afrasiabi Hossein Goudarzi Ali Hashemi Mohammad Reza Arabestani
author_facet	Mahdane Roshani Alireza Goodarzi Sanaz Dehbashi Farhad Afrasiabi Hossein Goudarzi Ali Hashemi Mohammad Reza Arabestani
author_sort	Mahdane Roshani
title	New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports
title_short	New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports
title_full	New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports
title_fullStr	New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports
title_full_unstemmed	New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports
title_sort	new delhi metallo-β-lactamase-1 among escherichia coli strains isolated from leukemia patients in iran: two case reports
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b721fadf8fe244c7b0715b378308f370
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New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports

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