Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes

Background: Medicinal plants have proven their value as a source of molecules with therapeutic potential, and recent studies have shown that capsaicin has profound anticancer effects in several types of human cancers. However, its clinical use is handicapped due to its poor pharmacokinetics. This st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ali Al-Samydai, Walhan Alshaer, Emad A. S. Al-Dujaili, Hanan Azzam, Talal Aburjai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anticancer <i>Capsicum annuum</i> capsaicin nanoliposomes polymer-based nanocarriers release kinetics Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b7239fcd422341248863f7f68637c6ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b7239fcd422341248863f7f68637c6ce
record_format	dspace
spelling	oai:doaj.org-article:b7239fcd422341248863f7f68637c6ce2021-11-25T18:35:54ZPreparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes10.3390/nu131139952072-6643https://doaj.org/article/b7239fcd422341248863f7f68637c6ce2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3995https://doaj.org/toc/2072-6643Background: Medicinal plants have proven their value as a source of molecules with therapeutic potential, and recent studies have shown that capsaicin has profound anticancer effects in several types of human cancers. However, its clinical use is handicapped due to its poor pharmacokinetics. This study aims to enhance capsaicin’s pharmacokinetic properties by loading the molecule into nanoliposomes model and testing its anticancer activity. Methods: Nanoliposomes were prepared using the thin-film method, and characteristics were examined followed by qualitative and quantitative analyses of encapsulation efficiency and drug loading using HPLC at different lipid/capsaicin ratios. Cell viability assay (MTT) was used to determine IC<sub>50</sub>. Results: Capsaicin-loaded nanoliposomes showed optimum characteristics of morphology, particle size, zeta potential, and stability. In vitro anticancer activity of capsaicin and capsaicin-loaded nanoliposomes were compared against MCF7, MDA-MB-231, K562, PANC1, and A375 cell lines. Capsaicin-loaded nanoliposomes showed significant improvement in anticancer activity against cancers cell lines studied (<i>p</i> < 0.001), with increased selectivity against cancer cells compared to capsaicin. Conclusion: The encapsulated capsaicin nanoliposomes produced an improvement in pharmacokinetics properties, enhancing the anticancer activity and selectivity compared with capsaicin. This model seems to offer a potential for developing capsaicin formulations for the prevention and treatment of cancer.Ali Al-SamydaiWalhan AlshaerEmad A. S. Al-DujailiHanan AzzamTalal AburjaiMDPI AGarticleanticancer<i>Capsicum annuum</i>capsaicinnanoliposomespolymer-based nanocarriersrelease kineticsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3995, p 3995 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer <i>Capsicum annuum</i> capsaicin nanoliposomes polymer-based nanocarriers release kinetics Nutrition. Foods and food supply TX341-641
spellingShingle	anticancer <i>Capsicum annuum</i> capsaicin nanoliposomes polymer-based nanocarriers release kinetics Nutrition. Foods and food supply TX341-641 Ali Al-Samydai Walhan Alshaer Emad A. S. Al-Dujaili Hanan Azzam Talal Aburjai Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
description	Background: Medicinal plants have proven their value as a source of molecules with therapeutic potential, and recent studies have shown that capsaicin has profound anticancer effects in several types of human cancers. However, its clinical use is handicapped due to its poor pharmacokinetics. This study aims to enhance capsaicin’s pharmacokinetic properties by loading the molecule into nanoliposomes model and testing its anticancer activity. Methods: Nanoliposomes were prepared using the thin-film method, and characteristics were examined followed by qualitative and quantitative analyses of encapsulation efficiency and drug loading using HPLC at different lipid/capsaicin ratios. Cell viability assay (MTT) was used to determine IC<sub>50</sub>. Results: Capsaicin-loaded nanoliposomes showed optimum characteristics of morphology, particle size, zeta potential, and stability. In vitro anticancer activity of capsaicin and capsaicin-loaded nanoliposomes were compared against MCF7, MDA-MB-231, K562, PANC1, and A375 cell lines. Capsaicin-loaded nanoliposomes showed significant improvement in anticancer activity against cancers cell lines studied (<i>p</i> < 0.001), with increased selectivity against cancer cells compared to capsaicin. Conclusion: The encapsulated capsaicin nanoliposomes produced an improvement in pharmacokinetics properties, enhancing the anticancer activity and selectivity compared with capsaicin. This model seems to offer a potential for developing capsaicin formulations for the prevention and treatment of cancer.
format	article
author	Ali Al-Samydai Walhan Alshaer Emad A. S. Al-Dujaili Hanan Azzam Talal Aburjai
author_facet	Ali Al-Samydai Walhan Alshaer Emad A. S. Al-Dujaili Hanan Azzam Talal Aburjai
author_sort	Ali Al-Samydai
title	Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
title_short	Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
title_full	Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
title_fullStr	Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
title_full_unstemmed	Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes
title_sort	preparation, characterization, and anticancer effects of capsaicin-loaded nanoliposomes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b7239fcd422341248863f7f68637c6ce
work_keys_str_mv	AT alialsamydai preparationcharacterizationandanticancereffectsofcapsaicinloadednanoliposomes AT walhanalshaer preparationcharacterizationandanticancereffectsofcapsaicinloadednanoliposomes AT emadasaldujaili preparationcharacterizationandanticancereffectsofcapsaicinloadednanoliposomes AT hananazzam preparationcharacterizationandanticancereffectsofcapsaicinloadednanoliposomes AT talalaburjai preparationcharacterizationandanticancereffectsofcapsaicinloadednanoliposomes
_version_	1718410973043228672

Preparation, Characterization, and Anticancer Effects of Capsaicin-Loaded Nanoliposomes

Ejemplares similares