Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia

Abstract In cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compa...

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Autores principales:	Pavel Hok, Lenka Hvizdošová, Pavel Otruba, Michaela Kaiserová, Markéta Trnečková, Zbyněk Tüdös, Petr Hluštík, Petr Kaňovský, Martin Nevrlý
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7258ebea5c54213a9e8987f9a94e3fe
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spelling	oai:doaj.org-article:b7258ebea5c54213a9e8987f9a94e3fe2021-12-02T18:02:48ZBotulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia10.1038/s41598-021-87088-z2045-2322https://doaj.org/article/b7258ebea5c54213a9e8987f9a94e3fe2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87088-zhttps://doaj.org/toc/2045-2322Abstract In cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compare connectivity between cerebellar subdivisions and the rest of the brain before and after BoNT treatment. Seventeen patients with cervical dystonia indicated for treatment with BoNT were enrolled (14 female, aged 50.2 ± 8.5 years, range 38–63 years). Clinical and fMRI examinations were carried out before and 4 weeks after BoNT injection. Clinical severity was evaluated using TWSTRS. Functional MRI data were acquired on a 1.5 T scanner during 8 min rest. Seed-based functional connectivity analysis was performed using data extracted from atlas-defined cerebellar areas in both datasets. Clinical scores demonstrated satisfactory BoNT effect. After treatment, connectivity decreased between the vermis lobule VIIIa and the left dorsal mesial frontal cortex. Positive correlations between the connectivity differences and the clinical improvement were detected for the right lobule VI, right crus II, vermis VIIIb and the right lobule IX. Our data provide evidence for modulation of cerebello-cortical connectivity resulting from successful treatment by botulinum neurotoxin.Pavel HokLenka HvizdošováPavel OtrubaMichaela KaiserováMarkéta TrnečkováZbyněk TüdösPetr HluštíkPetr KaňovskýMartin NevrlýNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pavel Hok Lenka Hvizdošová Pavel Otruba Michaela Kaiserová Markéta Trnečková Zbyněk Tüdös Petr Hluštík Petr Kaňovský Martin Nevrlý Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
description	Abstract In cervical dystonia, functional MRI (fMRI) evidence indicates changes in several resting state networks, which revert in part following the botulinum neurotoxin A (BoNT) therapy. Recently, the involvement of the cerebellum in dystonia has gained attention. The aim of our study was to compare connectivity between cerebellar subdivisions and the rest of the brain before and after BoNT treatment. Seventeen patients with cervical dystonia indicated for treatment with BoNT were enrolled (14 female, aged 50.2 ± 8.5 years, range 38–63 years). Clinical and fMRI examinations were carried out before and 4 weeks after BoNT injection. Clinical severity was evaluated using TWSTRS. Functional MRI data were acquired on a 1.5 T scanner during 8 min rest. Seed-based functional connectivity analysis was performed using data extracted from atlas-defined cerebellar areas in both datasets. Clinical scores demonstrated satisfactory BoNT effect. After treatment, connectivity decreased between the vermis lobule VIIIa and the left dorsal mesial frontal cortex. Positive correlations between the connectivity differences and the clinical improvement were detected for the right lobule VI, right crus II, vermis VIIIb and the right lobule IX. Our data provide evidence for modulation of cerebello-cortical connectivity resulting from successful treatment by botulinum neurotoxin.
format	article
author	Pavel Hok Lenka Hvizdošová Pavel Otruba Michaela Kaiserová Markéta Trnečková Zbyněk Tüdös Petr Hluštík Petr Kaňovský Martin Nevrlý
author_facet	Pavel Hok Lenka Hvizdošová Pavel Otruba Michaela Kaiserová Markéta Trnečková Zbyněk Tüdös Petr Hluštík Petr Kaňovský Martin Nevrlý
author_sort	Pavel Hok
title	Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
title_short	Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
title_full	Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
title_fullStr	Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
title_full_unstemmed	Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
title_sort	botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7258ebea5c54213a9e8987f9a94e3fe
work_keys_str_mv	AT pavelhok botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT lenkahvizdosova botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT pavelotruba botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT michaelakaiserova botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT marketatrneckova botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT zbynektudos botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT petrhlustik botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT petrkanovsky botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia AT martinnevrly botulinumtoxininjectionchangesrestingstatecerebellarconnectivityincervicaldystonia
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Botulinum toxin injection changes resting state cerebellar connectivity in cervical dystonia

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