Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
Altered fatty acid intake during pregnancy is associated with neurodevelopmental disorders. Here, the authors show that maternal omega-3 fatty acids deficiency results in altered microglia-mediated phagocytosis of synaptic elements leading to impaired cognitive functions in the offspring in mice.
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Nature Portfolio
2020
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oai:doaj.org-article:b725bc2bf26347258abab184e07e51972021-12-02T17:32:28ZEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain10.1038/s41467-020-19861-z2041-1723https://doaj.org/article/b725bc2bf26347258abab184e07e51972020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19861-zhttps://doaj.org/toc/2041-1723Altered fatty acid intake during pregnancy is associated with neurodevelopmental disorders. Here, the authors show that maternal omega-3 fatty acids deficiency results in altered microglia-mediated phagocytosis of synaptic elements leading to impaired cognitive functions in the offspring in mice.C. MadoreQ. LeyrolleL. MorelM. RossittoA. D. GreenhalghJ. C. DelpechM. MartinatC. Bosch-BoujuJ. BourelB. RaniC. LacabanneA. ThomazeauK. E. HoppertonS. BeccariA. SereA. AubertV. De Smedt-PeyrusseC. LecoursK. BishtL. FourgeaudS. GregoireL. BretillonN. AcarN. J. GrantJ. BadautP. GressensA. SierraO. ButovskyM. E. TremblayR. P. BazinetC. JoffreA. NadjarS. LayéNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q C. Madore Q. Leyrolle L. Morel M. Rossitto A. D. Greenhalgh J. C. Delpech M. Martinat C. Bosch-Bouju J. Bourel B. Rani C. Lacabanne A. Thomazeau K. E. Hopperton S. Beccari A. Sere A. Aubert V. De Smedt-Peyrusse C. Lecours K. Bisht L. Fourgeaud S. Gregoire L. Bretillon N. Acar N. J. Grant J. Badaut P. Gressens A. Sierra O. Butovsky M. E. Tremblay R. P. Bazinet C. Joffre A. Nadjar S. Layé Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain |
| description |
Altered fatty acid intake during pregnancy is associated with neurodevelopmental disorders. Here, the authors show that maternal omega-3 fatty acids deficiency results in altered microglia-mediated phagocytosis of synaptic elements leading to impaired cognitive functions in the offspring in mice. |
| format |
article |
| author |
C. Madore Q. Leyrolle L. Morel M. Rossitto A. D. Greenhalgh J. C. Delpech M. Martinat C. Bosch-Bouju J. Bourel B. Rani C. Lacabanne A. Thomazeau K. E. Hopperton S. Beccari A. Sere A. Aubert V. De Smedt-Peyrusse C. Lecours K. Bisht L. Fourgeaud S. Gregoire L. Bretillon N. Acar N. J. Grant J. Badaut P. Gressens A. Sierra O. Butovsky M. E. Tremblay R. P. Bazinet C. Joffre A. Nadjar S. Layé |
| author_facet |
C. Madore Q. Leyrolle L. Morel M. Rossitto A. D. Greenhalgh J. C. Delpech M. Martinat C. Bosch-Bouju J. Bourel B. Rani C. Lacabanne A. Thomazeau K. E. Hopperton S. Beccari A. Sere A. Aubert V. De Smedt-Peyrusse C. Lecours K. Bisht L. Fourgeaud S. Gregoire L. Bretillon N. Acar N. J. Grant J. Badaut P. Gressens A. Sierra O. Butovsky M. E. Tremblay R. P. Bazinet C. Joffre A. Nadjar S. Layé |
| author_sort |
C. Madore |
| title |
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain |
| title_short |
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain |
| title_full |
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain |
| title_fullStr |
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain |
| title_full_unstemmed |
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain |
| title_sort |
essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/b725bc2bf26347258abab184e07e5197 |
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