Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices

Behavioral flexibility depends on neuronal plasticity which forms and adapts the central nervous system in an experience-dependent manner. Thus, plasticity depends on interactions between the organism and its environment. A key experimental paradigm for studying this concept is the exposure of roden...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lucie Landeck, Martin E. Kaiser, Dimitri Hefter, Andreas Draguhn, Martin Both
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hippocampus sharp waves ripples plasticity network oscillations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/b727d74dc76a4da49ae5c3f471fb1a2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b727d74dc76a4da49ae5c3f471fb1a2e
record_format	dspace
spelling	oai:doaj.org-article:b727d74dc76a4da49ae5c3f471fb1a2e2021-12-03T06:35:34ZEnriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices1662-511010.3389/fncir.2021.758939https://doaj.org/article/b727d74dc76a4da49ae5c3f471fb1a2e2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncir.2021.758939/fullhttps://doaj.org/toc/1662-5110Behavioral flexibility depends on neuronal plasticity which forms and adapts the central nervous system in an experience-dependent manner. Thus, plasticity depends on interactions between the organism and its environment. A key experimental paradigm for studying this concept is the exposure of rodents to an enriched environment (EE), followed by studying differences to control animals kept under standard conditions (SC). While multiple changes induced by EE have been found at the cellular-molecular and cognitive-behavioral levels, little is known about EE-dependent alterations at the intermediate level of network activity. We, therefore, studied spontaneous network activity in hippocampal slices from mice which had previously experienced EE for 10–15 days. Compared to control animals from standard conditions (SC) and mice with enhanced motor activity (MC) we found several differences in sharp wave-ripple complexes (SPW-R), a memory-related activity pattern. Sharp wave amplitude, unit firing during sharp waves, and the number of superimposed ripple cycles were increased in tissue from the EE group. On the other hand, spiking precision with respect to the ripple oscillations was reduced. Recordings from single pyramidal cells revealed a reduction in synaptic inhibition during SPW-R together with a reduced inhibition-excitation ratio. The number of inhibitory neurons, including parvalbumin-positive interneurons, was unchanged. Altered activation or efficacy of synaptic inhibition may thus underlie changes in memory-related network activity patterns which, in turn, may be important for the cognitive-behavioral effects of EE exposure.Lucie LandeckMartin E. KaiserDimitri HefterDimitri HefterAndreas DraguhnMartin BothFrontiers Media S.A.articlehippocampussharp wavesripplesplasticitynetwork oscillationsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neural Circuits, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hippocampus sharp waves ripples plasticity network oscillations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	hippocampus sharp waves ripples plasticity network oscillations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lucie Landeck Martin E. Kaiser Dimitri Hefter Dimitri Hefter Andreas Draguhn Martin Both Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices
description	Behavioral flexibility depends on neuronal plasticity which forms and adapts the central nervous system in an experience-dependent manner. Thus, plasticity depends on interactions between the organism and its environment. A key experimental paradigm for studying this concept is the exposure of rodents to an enriched environment (EE), followed by studying differences to control animals kept under standard conditions (SC). While multiple changes induced by EE have been found at the cellular-molecular and cognitive-behavioral levels, little is known about EE-dependent alterations at the intermediate level of network activity. We, therefore, studied spontaneous network activity in hippocampal slices from mice which had previously experienced EE for 10–15 days. Compared to control animals from standard conditions (SC) and mice with enhanced motor activity (MC) we found several differences in sharp wave-ripple complexes (SPW-R), a memory-related activity pattern. Sharp wave amplitude, unit firing during sharp waves, and the number of superimposed ripple cycles were increased in tissue from the EE group. On the other hand, spiking precision with respect to the ripple oscillations was reduced. Recordings from single pyramidal cells revealed a reduction in synaptic inhibition during SPW-R together with a reduced inhibition-excitation ratio. The number of inhibitory neurons, including parvalbumin-positive interneurons, was unchanged. Altered activation or efficacy of synaptic inhibition may thus underlie changes in memory-related network activity patterns which, in turn, may be important for the cognitive-behavioral effects of EE exposure.
format	article
author	Lucie Landeck Martin E. Kaiser Dimitri Hefter Dimitri Hefter Andreas Draguhn Martin Both
author_facet	Lucie Landeck Martin E. Kaiser Dimitri Hefter Dimitri Hefter Andreas Draguhn Martin Both
author_sort	Lucie Landeck
title	Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices
title_short	Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices
title_full	Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices
title_fullStr	Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices
title_full_unstemmed	Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices
title_sort	enriched environment modulates sharp wave-ripple (spw-r) activity in hippocampal slices
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b727d74dc76a4da49ae5c3f471fb1a2e
work_keys_str_mv	AT lucielandeck enrichedenvironmentmodulatessharpwaveripplespwractivityinhippocampalslices AT martinekaiser enrichedenvironmentmodulatessharpwaveripplespwractivityinhippocampalslices AT dimitrihefter enrichedenvironmentmodulatessharpwaveripplespwractivityinhippocampalslices AT dimitrihefter enrichedenvironmentmodulatessharpwaveripplespwractivityinhippocampalslices AT andreasdraguhn enrichedenvironmentmodulatessharpwaveripplespwractivityinhippocampalslices AT martinboth enrichedenvironmentmodulatessharpwaveripplespwractivityinhippocampalslices
_version_	1718373892470341632

Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices

Ejemplares similares