Strategies to apply 3Rs in preclinical testing

Abstract Animal experimentation has been fundamental in biological and biomedical research. To guarantee the maximum quality, efficacy and/or safety of products intended for the use in humans in vivo testing is necessary; however, for over 60 years, alternative methods have been developed in respons...

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Autores principales:	Susana B. Gorzalczany, Angeles G. Rodriguez Basso
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	non clinical reduction refinement replacement testing approaches Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b7348bda41d3455d9b2921ea78a704b5
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spelling	oai:doaj.org-article:b7348bda41d3455d9b2921ea78a704b52021-11-16T13:45:54ZStrategies to apply 3Rs in preclinical testing2052-170710.1002/prp2.863https://doaj.org/article/b7348bda41d3455d9b2921ea78a704b52021-10-01T00:00:00Zhttps://doi.org/10.1002/prp2.863https://doaj.org/toc/2052-1707Abstract Animal experimentation has been fundamental in biological and biomedical research. To guarantee the maximum quality, efficacy and/or safety of products intended for the use in humans in vivo testing is necessary; however, for over 60 years, alternative methods have been developed in response to the necessity to reduce the number of animals used in experimentation, to guarantee their welfare; resorting to animal models only when strictly necessary. The three Rs (Replacement, Reduction, and Refinement), seek to ensure the rational and respectful use of laboratory animals and maintain an adequate projection in terms of bioethical considerations. This article describes different approaches to apply 3Rs in preclinical experimentation for either research or regulatory purposes.Susana B. GorzalczanyAngeles G. Rodriguez BassoWileyarticlenon clinicalreductionrefinementreplacementtesting approachesTherapeutics. PharmacologyRM1-950ENPharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non clinical reduction refinement replacement testing approaches Therapeutics. Pharmacology RM1-950
spellingShingle	non clinical reduction refinement replacement testing approaches Therapeutics. Pharmacology RM1-950 Susana B. Gorzalczany Angeles G. Rodriguez Basso Strategies to apply 3Rs in preclinical testing
description	Abstract Animal experimentation has been fundamental in biological and biomedical research. To guarantee the maximum quality, efficacy and/or safety of products intended for the use in humans in vivo testing is necessary; however, for over 60 years, alternative methods have been developed in response to the necessity to reduce the number of animals used in experimentation, to guarantee their welfare; resorting to animal models only when strictly necessary. The three Rs (Replacement, Reduction, and Refinement), seek to ensure the rational and respectful use of laboratory animals and maintain an adequate projection in terms of bioethical considerations. This article describes different approaches to apply 3Rs in preclinical experimentation for either research or regulatory purposes.
format	article
author	Susana B. Gorzalczany Angeles G. Rodriguez Basso
author_facet	Susana B. Gorzalczany Angeles G. Rodriguez Basso
author_sort	Susana B. Gorzalczany
title	Strategies to apply 3Rs in preclinical testing
title_short	Strategies to apply 3Rs in preclinical testing
title_full	Strategies to apply 3Rs in preclinical testing
title_fullStr	Strategies to apply 3Rs in preclinical testing
title_full_unstemmed	Strategies to apply 3Rs in preclinical testing
title_sort	strategies to apply 3rs in preclinical testing
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/b7348bda41d3455d9b2921ea78a704b5
work_keys_str_mv	AT susanabgorzalczany strategiestoapply3rsinpreclinicaltesting AT angelesgrodriguezbasso strategiestoapply3rsinpreclinicaltesting
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Strategies to apply 3Rs in preclinical testing

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