Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Ehsan Samei1,2,3,4, Robert S Saunders1, Cristian T Badea2,5, Ketan B Ghaghada2,5&dagger;, Laurence W Hedlund2,5, Yi Qi2,5, Hong Yuan6, Rex&nbsp;C Bentley7, Srinivasan Mukundan Jr2,3,5*1Carl&nbsp;E Ravin Advanced Imaging Laboratories, 2Department of Radiology, 3Department of B...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ehsan Samei, Robert S Saunders, Cristian T Badea, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b7357a98e01946e6b4cf3646f39a6f51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b7357a98e01946e6b4cf3646f39a6f51
record_format	dspace
spelling	oai:doaj.org-article:b7357a98e01946e6b4cf3646f39a6f512021-12-02T02:48:32ZMicro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent1176-91141178-2013https://doaj.org/article/b7357a98e01946e6b4cf3646f39a6f512009-11-01T00:00:00Zhttp://www.dovepress.com/micro-ct-imaging-of-breast-tumors-in-rodents-using-a-liposomal-nanopar-a3758https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ehsan Samei1,2,3,4, Robert S Saunders1, Cristian T Badea2,5, Ketan B Ghaghada2,5&dagger;, Laurence W Hedlund2,5, Yi Qi2,5, Hong Yuan6, Rex&nbsp;C Bentley7, Srinivasan Mukundan Jr2,3,51Carl&nbsp;E Ravin Advanced Imaging Laboratories, 2Department of Radiology, 3Department of Biomedical Engineering, 4Department of Physics, 5Center for In Vivo Microscopy, 6Department of Radiation Oncology, 7Department of Pathology, Duke University, Durham, NC, USA; &dagger;Current address: School of Health Information Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA; Current address: Department of Radiology, Brigham and Women&rsquo;s Hospital, Boston, MA, USAAbstract: A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.Keywords: molecular imaging, liposome, angiogenesis, breast cancer, small animal imaging, micro-CT Ehsan SameiRobert S SaundersCristian T Badeaet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 277-282 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ehsan Samei Robert S Saunders Cristian T Badea et al Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
description	Ehsan Samei1,2,3,4, Robert S Saunders1, Cristian T Badea2,5, Ketan B Ghaghada2,5&dagger;, Laurence W Hedlund2,5, Yi Qi2,5, Hong Yuan6, Rex&nbsp;C Bentley7, Srinivasan Mukundan Jr2,3,51Carl&nbsp;E Ravin Advanced Imaging Laboratories, 2Department of Radiology, 3Department of Biomedical Engineering, 4Department of Physics, 5Center for In Vivo Microscopy, 6Department of Radiation Oncology, 7Department of Pathology, Duke University, Durham, NC, USA; &dagger;Current address: School of Health Information Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA; Current address: Department of Radiology, Brigham and Women&rsquo;s Hospital, Boston, MA, USAAbstract: A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.Keywords: molecular imaging, liposome, angiogenesis, breast cancer, small animal imaging, micro-CT
format	article
author	Ehsan Samei Robert S Saunders Cristian T Badea et al
author_facet	Ehsan Samei Robert S Saunders Cristian T Badea et al
author_sort	Ehsan Samei
title	Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_short	Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_full	Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_fullStr	Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_full_unstemmed	Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_sort	micro-ct imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/b7357a98e01946e6b4cf3646f39a6f51
work_keys_str_mv	AT ehsansamei microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent AT robertssaunders microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent AT cristiantbadea microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent AT etal microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
_version_	1718402122041524224

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

Ejemplares similares