Major histocompatibility complex genes partly explain early survival in house sparrows

Abstract Environmental factors and genetic incompatibilities between parents have been suggested as important determinants for embryonic mortality and survival. The genetic set-up of the immune system, specifically the highly polymorphic major histocompatibility complex (MHC) may also influence indi...

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Autores principales:	B. Lukasch, H. Westerdahl, M. Strandh, F. Knauer, H. Winkler, Y. Moodley, H. Hoi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7387359bad84f8abec066ad882b669f
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spelling	oai:doaj.org-article:b7387359bad84f8abec066ad882b669f2021-12-02T16:06:39ZMajor histocompatibility complex genes partly explain early survival in house sparrows10.1038/s41598-017-06631-z2045-2322https://doaj.org/article/b7387359bad84f8abec066ad882b669f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06631-zhttps://doaj.org/toc/2045-2322Abstract Environmental factors and genetic incompatibilities between parents have been suggested as important determinants for embryonic mortality and survival. The genetic set-up of the immune system, specifically the highly polymorphic major histocompatibility complex (MHC) may also influence individual resistance to infections. MHC proteins are important for an appropriate adaptive immune response and enable T-cells to separate ‘self’ from ‘non-self’. Here we investigate the importance of MHC functional diversity for early development in birds, more specifically, if offspring survival and body mass or size depends on number of different functional MHC alleles, specific functional MHC alleles or similarity of MHC alleles in the parents. Unhatched eggs are common in clutches of many bird species. In house sparrows (Passer domesticus), embryo and nestling mortality can exceed 50%. To control for environmental factors, our study was carried out on an aviary population. We found that one specific functional MHC allele was associated with reduced nestling survival, which was additionally supported by lower body mass and a smaller tarsus when nestlings have been 6 days old. Another allele was positively associated with tarsus length at a later nestling stage (nestlings 12 days old). These results indicate that MHC alleles might influence pathogen resistance or susceptibility.B. LukaschH. WesterdahlM. StrandhF. KnauerH. WinklerY. MoodleyH. HoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. Lukasch H. Westerdahl M. Strandh F. Knauer H. Winkler Y. Moodley H. Hoi Major histocompatibility complex genes partly explain early survival in house sparrows
description	Abstract Environmental factors and genetic incompatibilities between parents have been suggested as important determinants for embryonic mortality and survival. The genetic set-up of the immune system, specifically the highly polymorphic major histocompatibility complex (MHC) may also influence individual resistance to infections. MHC proteins are important for an appropriate adaptive immune response and enable T-cells to separate ‘self’ from ‘non-self’. Here we investigate the importance of MHC functional diversity for early development in birds, more specifically, if offspring survival and body mass or size depends on number of different functional MHC alleles, specific functional MHC alleles or similarity of MHC alleles in the parents. Unhatched eggs are common in clutches of many bird species. In house sparrows (Passer domesticus), embryo and nestling mortality can exceed 50%. To control for environmental factors, our study was carried out on an aviary population. We found that one specific functional MHC allele was associated with reduced nestling survival, which was additionally supported by lower body mass and a smaller tarsus when nestlings have been 6 days old. Another allele was positively associated with tarsus length at a later nestling stage (nestlings 12 days old). These results indicate that MHC alleles might influence pathogen resistance or susceptibility.
format	article
author	B. Lukasch H. Westerdahl M. Strandh F. Knauer H. Winkler Y. Moodley H. Hoi
author_facet	B. Lukasch H. Westerdahl M. Strandh F. Knauer H. Winkler Y. Moodley H. Hoi
author_sort	B. Lukasch
title	Major histocompatibility complex genes partly explain early survival in house sparrows
title_short	Major histocompatibility complex genes partly explain early survival in house sparrows
title_full	Major histocompatibility complex genes partly explain early survival in house sparrows
title_fullStr	Major histocompatibility complex genes partly explain early survival in house sparrows
title_full_unstemmed	Major histocompatibility complex genes partly explain early survival in house sparrows
title_sort	major histocompatibility complex genes partly explain early survival in house sparrows
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b7387359bad84f8abec066ad882b669f
work_keys_str_mv	AT blukasch majorhistocompatibilitycomplexgenespartlyexplainearlysurvivalinhousesparrows AT hwesterdahl majorhistocompatibilitycomplexgenespartlyexplainearlysurvivalinhousesparrows AT mstrandh majorhistocompatibilitycomplexgenespartlyexplainearlysurvivalinhousesparrows AT fknauer majorhistocompatibilitycomplexgenespartlyexplainearlysurvivalinhousesparrows AT hwinkler majorhistocompatibilitycomplexgenespartlyexplainearlysurvivalinhousesparrows AT ymoodley majorhistocompatibilitycomplexgenespartlyexplainearlysurvivalinhousesparrows AT hhoi majorhistocompatibilitycomplexgenespartlyexplainearlysurvivalinhousesparrows
_version_	1718384925882712064

Major histocompatibility complex genes partly explain early survival in house sparrows

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